LYTAC Building Blocks provide an advanced starting point for LYTAC development. LYTAC (LYsosome TArgeting Chimera) molecules are a new approach to Targeted Protein Degradation, which direct an extracellular protein of interest to the lysosome for degradation. LYTACs are heterobifunctional molecules comprising a recruiting molecule for a target protein (e.g. an antibody) joined by a linker to a ligand for a cell surface receptor, such as the cation-independent mannose-6-phosphate receptor (CI-M6PR) or the asialoglycoprotein receptor (ASGPR). The LYTAC forms a ternary complex with the protein of interest and the receptor, triggering internalization of the target protein via endocytosis and its subsequent lysosomal degradation.
