Mnk Inhibitors

Mitogen-activated protein kinase (MAPK) interacting protein kinases (Mnks) are a family of serine/threonine kinases of which there are four isoforms; Mnk1a, Mnk1b, Mnk2a and Mnk2b. Mnk1a/2a are downstream effectors of MAPK signaling, and have been implicated in oncogenic transformation and progression.

Structurally Mnk1a/2a consists of an N-terminal region that mediates protein localization, a catalytic domain and a C-terminus that contains a MAPK binding domain. The b isoforms differ slightly ...