MAPK Signaling
The mitogen-activated protein kinase (MAPK) family is a group of serine/threonine kinases that mediate intracellular signaling. The activation of MAPK involves a cascade consisting of MAPK kinase (also known as MAPKKK or MEKK) that activates MAPK/ERK (also known as MAPKK or MEK). This stimulates a phosphorylation-dependent increase in the activity of MAPK.
MAPK Signaling Targets
AP-1 (AP-1) | MK2 (MAPKAPK2) |
ASK1 (ASK1) | Mnk |
MAPK Family | MYC (MYC) |
Raf Kinases (Raf Kinases) |
Upon activation, MAPK can phosphorylate a variety of intracellular targets including transcription factors, transcriptional adaptor proteins, membrane and cytoplasmic substrates, and other protein kinases. Three major groups of MAPK cascades have been determined: ERK1/ERK2, JNK/SAPK and p38 MAPK.
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
MAPK Signaling Pathway
The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.