4 results for "Nicotinic Acetylcholine R alpha 7/CHRNA7 Small Molecules and Peptides" in 产品
Nicotinic Acetylcholine R alpha 7/CHRNA7 Small Molecules and Peptides
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. nAChR alpha 7/CHRNA7 forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once nAChR alpha 7/CHRNA7 binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Selective α7 neuronal nAChR antagonist
| Alternate Names: | MLA |
| Chemical Name: | [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate |
| Purity: | ≥95% |
Broad spectrum glutamatergic antagonist
| Chemical Name: | 4-Hydroxyquinoline-2-carboxylic acid |
| Purity: | ≥98% |
Selective α7 nAChR antagonist
| Alternate Names: | α-Bgtx,α-BuTX |
| Purity: | ≥98% |
Potent 5-HT3 antagonist; also α7 nAChR partial agonist
| Alternate Names: | Novaban,ICS 205930 |
| Chemical Name: | (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride |
| Purity: | ≥98% |
