6 results for "Nicotinic Acetylcholine R alpha 7/CHRNA7" in 产品
Nicotinic Acetylcholine R alpha 7/CHRNA7 Products
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. nAChR alpha 7/CHRNA7 forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once nAChR alpha 7/CHRNA7 binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Positive allosteric modulator of α7 nAChRs; active in vivo
| Chemical Name: | N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea |
| Purity: | ≥98% |
Positive allosteric modulator of α7 nAChRs; active in vivo
| Chemical Name: | N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea |
| Purity: | ≥98% |
Positive allosteric modulator of α7 nAChRs
| Alternate Names: | XY 4083 |
| Chemical Name: | [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide |
Allosteric potentiator of α7, α4β2 and α4β4 nAChRs
| Chemical Name: | [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone |
| Purity: | ≥98% |
Positive allosteric modulator of α7 nAChRs
| Chemical Name: | 4-[5-(4-Chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]benzenesulfonamide |
| Purity: | ≥97% |
Positive allosteric modulator of α7 nAChRs; analgesic
| Alternate Names: | (-)-(S)-B 973B |
| Chemical Name: | 3,4-Difluoro-N-[(1S)-1-[6-[4-(2-pyridinyl)-1-piperazinyl]-2-pyrazinyl]ethyl]benzenepropanamide |
| Purity: | ≥98% |
