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PGLYRP1/PGRP-S: Products
PGLYRP1/PGRP-S is a secreted peptidoglycan recognition protein that is expressed by neutrophils, eosinophils, and a variety of tissues including the gastrointestinal system, salivary glands, and mammary glands. It binds to TREM-1 and HSP70 and mediates host defense against Gram-positive bacteria.
PGLYRP1 protects against experimental colitis and experimental peptidoglycan-induced arthritis, although it can promote inflammation in dermatitis and house dust mite-induced airway allergy.
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