107 results for "Presenilin-2" in 产品

Presenilin-2 Products

Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.

γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

Chemical Name: (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester
Purity: ≥99%
Using DAPT to differentiate hiPSCs into dopaminergic neurons
(2)
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DAPT synthesized to Ancillary Material Grade

Chemical Name: (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine 1,1-dimethylethyl ester
Purity: ≥99%
DAPT synthesized to Ancillary Material Grade
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γ-secretase inhibitor; inhibits Notch pathway

Alternate Names: Dibenzazepine,YO-01027
Chemical Name: N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
Purity: ≥98%
γ-secretase inhibitor; inhibits Notch pathway
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Reactivity: Human, Mouse, Rat, Primate
Details: Mouse IgG1 Monoclonal Clone #APS 26
Applications: IHC, WB, ELISA, ICC/IF, IP
Western Blot: Presenilin-2 Antibody (APS 26) [NB100-74513]
(5)
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Reactivity: Human, Mouse, Rat, Primate
Details: Mouse IgG1 Monoclonal Clone #APS 21
Applications: IHC, WB, ELISA, ICC/IF
Western Blot: Presenilin-2 Antibody (APS 21) [NB100-74512]
(5)
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Potent γ-secretase inhibitor

Chemical Name: 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid
Purity: ≥98%
Potent γ-secretase inhibitor
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γ-secretase inhibitor; attenuates amyloid plaque deposition

Chemical Name: N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
Purity: ≥98%
γ-secretase inhibitor; attenuates amyloid plaque deposition
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Potent γ-secretase inhibitor

Chemical Name: (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide
Purity: ≥98%
Potent γ-secretase inhibitor
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Highly potent γ-secretase inhibitor; orally bioavailable

Alternate Names: BMS-708163
Chemical Name: (2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
Purity: ≥98%
Highly potent γ-secretase inhibitor; orally bioavailable
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γ-secretase pseudo-inhibitor

Chemical Name: (2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide
Purity: ≥98%
γ-secretase pseudo-inhibitor
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Reactivity: Human
Applications:
R&D Systems VersaClone cDNA Plasmids
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Reactivity: Human
Applications: WB
Western Blot: Presenilin-2 Overexpression Lysate [NBP2-10350]
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Reactivity: Human
Source: Wheat germ
Applications: WB, ELISA, AP, MA, PAGE
SDS-PAGE: Recombinant Human Presenilin-2 GST (N-Term) Protein [H00005664-Q01]
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