7 results for "RIP Kinase Inhibitors" in 产品
RIP Kinase Inhibitors
RIPK1 (Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 1), also known as RIP1, contains an N-terminal protein kinase domain, a C-terminal death domain, and a unique internal region called the intermediate domain. It is a serine/threonine protein kinase and is constitutively expressed in many tissues. RIPK1 interacts with the cytoplasmic death domain of FAS and TNF receptors, and is an important element in apoptotic processes. RIPK1 has been shown to interact with a number of proteins including TRADD, TRAF1, TRAF2, and TRAF3, to form larger signaling complexes. These complexes, in turn, activate specific signaling cascades, such as NFkB.
Potent RIPK2 inhibitor
| Chemical Name: | 3-(Benzoylamino)-4-methyl-N-[3-(1-methyl-1H-imidazol-2-yl)phenyl]benzamide |
| Purity: | ≥98% |
RIP1 kinase inhibitor; inhibits necroptosis
| Chemical Name: | 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone |
| Purity: | ≥98% |
Potent and metabolically stable RIP1 kinase inhibitor
| Chemical Name: | N-Hydroxy-2,2-dimethyl-N-(phenylmethyl)butanamide |
| Purity: | ≥98% |
Potent RIPK2 inhibitor; orally bioavailable and cell permeable
| Chemical Name: | 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine |
| Purity: | ≥98% |
Potent and selective RIP3 kinase inhibitor
| Chemical Name: | N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine |
| Purity: | ≥98% |
RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant
| Chemical Name: | N-[1,4-Dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]acetamide |
| Purity: | ≥98% |
Potent and selective RIPK3 inhibitor; also blocks activation of necroptosis
| Chemical Name: | 3-(3-Hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]-1,6-naphthyridin-2(1H)-one dihydrochloride |
| Purity: | ≥98% |
