RIP Kinase Modulators Small Molecules and Peptides

Receptor Interacting Protein (RIP) kinases are characterized by a homologous kinase domain, but have distinct non-kinase regions, which are key to the specific function of each RIP kinase. They have key roles in various biological processes, including innate immunity, inflammation and regulation of cell death.

RIP1-5 all have a N-terminal kinase domain. In addition to the kinase domain RIP1 contains an intermediate domain and a C-terminal death domain (DD), which binds to death receptors, ...