Stearoyl CoA 9 Desaturase Inhibitors

Stearoyl-CoA 9-desaturase (SCD-1, Δ9 desaturase), EC 1.14.19.1, is an enzyme that catalyzes the conversion of long-chain saturated fatty acids into monounsaturated fatty acids (MUFAs). It is important in energy expenditure, as well as glucose and lipid metabolism.

SCD-1 is expressed in most human and mouse tissues and is rate-limiting in the synthesis of MUFAs. It is an integral protein in the membrane of the endoplasmic reticulum. Two isoforms of the enzyme have been identified in ...