7 results for "TRPC6 Small Molecules and Peptides" in 产品

TRPC6 Small Molecules and Peptides

The protein encoded by the TRPC6 gene creates receptor-activated cation permeant calcium channels in the cell membrane. Isoform 1 is 931 amino acids in length and is approximately 106 kDa, while isoform 2 is 815 amino acids in lenth at around 93 kDA. Isoform 3 is 876 amino acids long and is just over 100 kDA. Focal segmental glomerulosclerosis 2 (FSGS2) is caused by deficits in the TRPC6 gene. This gene has been linked to diseases such as cystic fibrosis, gigantism, hypertension, kidney ...

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TRPC1 and TRPC6 inhibitor; inhibits mechanosensitive ion channels

Purity: ≥95%
TRPC1 and TRPC6 inhibitor; inhibits mechanosensitive ion channels
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Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

Chemical Name: 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
Purity: ≥98%
Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway
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TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion

Purity: ≥95%
TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion
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Potent and selective TRPC6 and TRPC3 antagonist

Chemical Name: [2-[(4-Chloro-2-fluorophenyl)amino]-5-methyl-4-thiazolyl][(2S,3S)-2,3-dimethyl-1-piperidinyl]methanone
Purity: ≥98%
Potent and selective TRPC6 and TRPC3 antagonist
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Potent and selective TRPC3/6 activator

Chemical Name: 1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
Purity: ≥98%
Potent and selective TRPC3/6 activator
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Potent TRPC6 inhibitor

Chemical Name: 4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile dihydrochloride
Purity: ≥98%
Potent TRPC6 inhibitor
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Selective positive allosteric modulator (PAM) of TRPC6

Chemical Name: 3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one
Purity: ≥98%
Selective positive allosteric modulator (PAM) of TRPC6
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