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182 results for "XIAP" in 产品
XIAP Products
XIAP (X-linked inhibitor of apoptosis) is a member of the Inhibitor of Apoptosis (IAP) protein family. XIAP inhibits the activity of caspase-3, -7, and -9. Caspase inhibition is reversed when SMAC/Diablo or HtrA2/Omi directly binds the BIR domain of XIAP.
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | KO, IHC, WB, Simple Western |
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| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2A Monoclonal Clone #117320 |
| Applications: | KO, WB |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, IP |
![Western Blot: XIAP Antibody [NB100-56183]](https://resources.rndsystems.com/images/products/XIAP-Antibody-Western-Blot-NB100-56183-img0006.jpg "Western Blot: XIAP Antibody [NB100-56183]")
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Contains 4 membranes - each spotted in duplicate with 35 different apoptosis antibodies
| Reactivity: | Human |
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| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #117318 |
| Applications: | IHC, B/N |
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| Reactivity: | Human |
| Source: | E. coli |
| Accession #: | AAC50373 |
| Applications: | Inhibition Activity |
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| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | KO, IHC, WB, ICC/IF |
![Knockout Validated: XIAP Antibody [NBP2-20918]](https://resources.rndsystems.com/images/products/XIAP-Antibody-Western-Blot-NBP2-20918-img0004.jpg "Western Blot: XIAP Antibody [NBP2-20918]")
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| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP |
![Immunohistochemistry: XIAP Antibody [NB100-56187]](https://resources.rndsystems.com/images/products/XIAP-Antibody-Immunohistochemistry-NB100-56187-img0001.jpg "Immunohistochemistry: XIAP Antibody [NB100-56187]")
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| Reactivity: | Human |
| Assay Range: | 312-20000 pg/mL |
| Applications: | ELISA |
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| Reactivity: | Human |
| Source: | E. coli |
| Accession #: | P98170 |
| Applications: | Inhibition Activity |
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Dimeric Smac mimetic; potent IAP inhibitor
| Chemical Name: | 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide |
| Purity: | ≥97% |
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High affinity XIAP antagonist; active in vivo
| Chemical Name: | N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-L-prolinamide hydrochloride |
| Purity: | ≥98% |
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| Reactivity: | Human |
| Source: | E. coli |
| Applications: | WB |
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| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #117305 |
| Applications: | ELISA |
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| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #117333 |
| Applications: | ELISA |
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IAP ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-[2-[2-2-[(2-aminoethoxy)ethoxy]ethoxy]acetamido]-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate |
| Purity: | ≥95% |
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IAP ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-[2-[2-(2-aminoethoxy)ethoxy]acetamido]-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate |
| Purity: | ≥95% |
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IAP ligand with alkyl linker and terminal amine for onward chemistry
| Chemical Name: | tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-(5-Aminopentanamido)-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate |
| Purity: | ≥95% |
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Potent and selective ERα Degrader (SNIPER)
| Chemical Name: | (2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide |
| Purity: | ≥98% |
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Functionalized IAP ligand for PROTACs
| Chemical Name: | tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate |
| Purity: | ≥95% |
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IAP ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | tert-Butyl ((S)-1-(((S)-2-((2S,4S)-4-(14-amino-3,6,9,12-tetraoxatetradecanamido)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate |
| Purity: | ≥95% |
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IAP ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | tert-Butyl ((S)-1-(((S)-2-((2S,4S)-4-(17-amino-3,6,9,12,15-pentaoxaheptadecanamido)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate |
| Purity: | ≥95% |
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| Reactivity: | Human |
| Source: | E. coli |
| Accession #: | U45880 |
| Applications: | Inhibition Activity |
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| Reactivity: | Human |
| Applications: | AC |
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Potent Lys-covalent pan-IAP inhibitor
| Chemical Name: | (R)-1-((S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamido)-2,3-dihydro-1H-inden-4-yl sulfurofluoridate |
| Purity: | ≥95% |
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