Catalog Number: 4488
Chemical Name: 3-β-D-Ribofuranosyl-3H-imidazo[4,5-b]pyridin-7-amine
Biological Activity
Inhibitor of adenosine deaminase (Ki = 0.66 μM). Demonstrates antitumor activity in a range of leukemia cell lines.
Technical Data
  • M.Wt:
    266.25
  • Formula:
    C11H14N4O4
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    14432-09-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Improved synthesis and antitumor activity of 1-deazaadenosine.
    Cristalli et al.
    J.Med.Chem., 1987;30:1686
  2. Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues.
    Cristalli et al.
    Drug Dev.Res., 1993;28:253
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 1-Deazaadenosine include:

1 Citations: Showing 1 - 1

  1. Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances.
    Authors: Li Et al.
    Anticancer Res 2015;3:e00121

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