1-Oleoyl lysophosphatidic acid sodium salt
Chemical Name: 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid sodium salt
Biological ActivityEndogenous agonist of the lysophospholipid receptors LPA1 and LPA2. Inhibits differentiation of neural stem cells (NSCs) into neurons.
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Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells.
Dottori M, Leung J, Turnley AM et al.
Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival.
Lapierre DM, Tanabe N, Pereverzev A
J. Biol. Chem., 2010;285(33):25792-801.
Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts.
van Corven et al.
Citation for 1-Oleoyl lysophosphatidic acid sodium salt
The citations listed below are publications that use Tocris products. Selected citations for 1-Oleoyl lysophosphatidic acid sodium salt include:
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Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.
Authors: Ruprecht Et al.
J Clin Invest 2015;160:673
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MG-63 cells were pre-incubated with indicated inhibitors for 30 min followed by treatment with 10 µM LPA for 3 h to follow COX-2 expression using Western blot. All inhibitors prevented COX-2 induction by LPA.
Primary mouse mammary glands were digested, incubated with LPA or control at 5uM and then analyzed using CD24/CD29 to identify effects on the stem cell pool. A 50% reduction in the stem cell pool (p4) was identified after LPA treatment.
MG-63 cells were treated with 10 µM LPA (0-48 h) to follow COX-2 expression using Western blot. LPA induced COX-2 expression in a time-dependent manner in osteosarcoma cells.