1-Oleoyl lysophosphatidic acid sodium salt

Tocris Bioscience | Catalog # 3854

Endogenous agonist of LPA1 and LPA2
Tocris Bioscience

Key Product Details

Description

Endogenous agonist of LPA1 and LPA2
View all Lysophosphatidic Acid (LPA) Receptor Agonists »

Product Description

1-Oleoyl lysophosphatidic acid sodium salt is an endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. 1-Oleoyl lysophosphatidic acid sodium salt inhibits differentiation of neural stem cells (NSCs) into neurons.

Note: This product is typically prepared in PBS, pH 7.2, at a concentration of up to approximately 4 mg/mL.

Product Specifications for 1-Oleoyl lysophosphatidic acid sodium salt

Molecular Weight

458.50

Formula

C21H40NaO7P

Storage

Store at -20°C

Chemical Name

1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid sodium salt

CAS Number

325465-93-8

PubChem ID

44159357

InChI Key

XGRLSUFHELJJAB-JGSYTFBMSA-M

SMILES

[Na+].CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

Product Documents for 1-Oleoyl lysophosphatidic acid sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 1-Oleoyl lysophosphatidic acid sodium salt

For research use only

Citations for 1-Oleoyl lysophosphatidic acid sodium salt

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  • LPA induces COX-2 expression in osteosacroma cells
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Verified Customer | Posted 12/13/2018
    MG-63 cells were pre-incubated with indicated inhibitors for 30 min followed by treatment with 10 µM LPA for 3 h to follow COX-2 expression using Western blot. All inhibitors prevented COX-2 induction by LPA.
    1-Oleoyl lysophosphatidic acid sodium salt 3854
  • Works to deplete stem cell pool
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: mammary gland
    Verified Customer | Posted 11/18/2018
    Primary mouse mammary glands were digested, incubated with LPA or control at 5uM and then analyzed using CD24/CD29 to identify effects on the stem cell pool. A 50% reduction in the stem cell pool (p4) was identified after LPA treatment.
    1-Oleoyl lysophosphatidic acid sodium salt 3854
  • LPA induces COX-2 expression in MG-63 cells
    Name: Christopher Trummer
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Verified Customer | Posted 10/23/2018
    MG-63 cells were treated with 10 µM LPA (0-48 h) to follow COX-2 expression using Western blot. LPA induced COX-2 expression in a time-dependent manner in osteosarcoma cells.
    1-Oleoyl lysophosphatidic acid sodium salt 3854

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