Chemical Name: 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride
Biological Activity10-DEBC hydrochloride is a selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Complete Your Experiment
Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells.
Thimmaiah et al.
Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling.
Thimmaiah et al.
Citations for 10-DEBC hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for 10-DEBC hydrochloride include:
6 Citations: Showing 1 - 6
TOR as a Regulatory Target in Rhipicephalus microplus Embryogenesis.
Authors: Waltero Et al.
Front Physiol 2019;10:965
Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1.
Authors: Ali Et al.
BMC Cancer 2017;17:803
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.
Authors: Liddell Et al.
J Neuroinflammation 2016;13:49
Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling.
Authors: Sokołowska Et al.
PLoS One 2014;52:48
Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.
Authors: Gangoiti Et al.
Inhibition of hepcidin transcription by growth factors.
Authors: Goodnough Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for 10-DEBC hydrochloride
There are currently no reviews for this product. Be the first to review 10-DEBC hydrochloride and earn rewards!
Have you used 10-DEBC hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image