Chemical Name: 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride
Biological Activity10-DEBC hydrochloride is a selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells.
Thimmaiah et al.
Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling.
Thimmaiah et al.
Citations for 10-DEBC hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for 10-DEBC hydrochloride include:
6 Citations: Showing 1 - 6
TOR as a Regulatory Target in Rhipicephalus microplus Embryogenesis.
Authors: Waltero Et al.
Front Physiol 2019;10:965
Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1.
Authors: Ali Et al.
BMC Cancer 2017;17:803
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.
Authors: Liddell Et al.
J Neuroinflammation 2016;13:49
Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling.
Authors: Sokołowska Et al.
PLoS One 2014;52:48
Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.
Authors: Gangoiti Et al.
Inhibition of hepcidin transcription by growth factors.
Authors: Goodnough Et al.
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As part of our current study, we investigated the role of AKT pathway on the LPA induced inflammatory phenotype in microglia (downstream signaling). BV2 cells were incubated for different time points with LPA (1µM) in the presence or absence of AKT X (5µM). AKT inhibition totally decreased the expression of 2 pro-inflammatory transcription factors (pSTAT1 and pp65). The inhibitor was diluted in water.