10-DEBC hydrochloride

Catalog # Availability Size / Price Qty
2558/10
2558/50
10-DEBC hydrochloride | CAS No. 925681-41-0 | Akt (Protein Kinase B) Inhibitors
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Description: Selective Akt/PKB inhibitor
Alternative Names: Akt Inhibitor X

Chemical Name: 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride

Purity: ≥99%

Product Details
Citations (6)
Supplemental Products
Reviews (1)

Biological Activity

Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.

Technical Data

M.Wt:
381.34
Formula:
C20H25N2OCl.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
925681-41-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells.
    Thimmaiah et al.
    J.Med.Chem., 1992;35:3358
  2. Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling.
    Thimmaiah et al.
    J.Biol.Chem., 2005;36:31924

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Citations for 10-DEBC hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for 10-DEBC hydrochloride include:

6 Citations: Showing 1 - 6

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Inhibition of Akt/PKB in BV2 microglia cells
By Joanna Plastira on 06/08/2019
Species: Mouse

As part of our current study, we investigated the role of AKT pathway on the LPA induced inflammatory phenotype in microglia (downstream signaling). BV2 cells were incubated for different time points with LPA (1µM) in the presence or absence of AKT X (5µM). AKT inhibition totally decreased the expression of 2 pro-inflammatory transcription factors (pSTAT1 and pp65). The inhibitor was diluted in water.


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