Catalog Number: 2558
Chemical Name: 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride
Biological Activity
Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.
Technical Data
  • M.Wt:
    381.34
  • Formula:
    C20H25N2OCl.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    925681-41-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells.
    Thimmaiah et al.
    J.Med.Chem., 1992;35:3358
  2. Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling.
    Thimmaiah et al.
    J.Biol.Chem., 2005;36:31924
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 10-DEBC hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling.
    Authors: Sokołowska Et al.
    PLoS One 2014;52:48
  2. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.
    Authors: Gangoiti Et al.
    Biochimie 2012;94:597
  3. Inhibition of hepcidin transcription by growth factors.
    Authors: Goodnough Et al.
    Hepatology 2012;56:291

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