10-DEBC hydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:2558
Chemical Name:10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.
Technical Data
  • M.Wt:
    381.34
  • Formula:
    C20H25N2OCl.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    925681-41-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 10-DEBC hydrochloride include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling.
    Authors: Sokołowska Et al.
    PLoS One  2014;52:48
  2. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.
    Authors: Gangoiti Et al.
    Biochimie  2012;94:597
  3. Inhibition of hepcidin transcription by growth factors.
    Authors: Goodnough Et al.
    Hepatology  2012;56:291

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used 10-DEBC hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee