Chemical Name: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Biological Activity10058-F4 is a cell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor growth in vivo. In lymphoma cells, 10058-F4 decreases glucose uptake and expression of glycolysis-associated genes and reduces cell viability.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Low molecular weight inhibitors of Myc-Max interaction and function.
Yin et al.
Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice.
Guo et al.
Cancer Chemother.Pharmacol., 2009;63:615
A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia.
Huang et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for 10058-F4
There are currently no reviews for this product. Be the first to review 10058-F4 and earn rewards!
Have you used 10058-F4?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image