Chemical Name: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Biological ActivityCell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor growth in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Low molecular weight inhibitors of Myc-Max interaction and function.
Yin et al.
Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice.
Guo et al.
Cancer Chemother.Pharmacol., 2009;63:615
A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia.
Huang et al.
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Used the compound for studying the anti-cancer properties. The compound 10058-F4, strongly induced caspase‐3‐dependent apoptosis in pre‐B ALL cells.