Catalog Number: 4406
Chemical Name: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Biological Activity
Cell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor growth in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice.
    Guo et al.
    Cancer Chemother.Pharmacol., 2009;63:615
  2. Low molecular weight inhibitors of Myc-Max interaction and function.
    Yin et al.
    Oncogene, 2003;22:6151
  3. A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia.
    Huang et al.
    Exp.Hematol., 2006;34:1480
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