Chemical Name: (5Z,12E,14E)-11-Oxo-prosta-5,9,12,14-tetraen-1-oic acid
Biological Activity15-deoxy-Δ-12,14-Prostaglandin J2 is a selective PPARγ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC50 = 7 μM).
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15-Deoxy-Δ12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ.
Forman et al.
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation.
Kliewer et al.
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Treatment of HL-1 cells (15 min) with increasing 15d-PGJ2 concentrations induced phosphorylation of p38 and p42/44 MAPK (shown in Image). A As pronounced MAPK activation was observed at 15 μM 15d-PGJ2.