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17-DMAG hydrochloride

2610 1 Citation Datasheet / COA / SDS
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2610/1

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17-DMAG hydrochloride | CAS No. 467214-21-7 | HSP90 Inhibitors
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Description: Water-soluble Hsp90 inhibitor
Alternative Names: NSC 707545

Chemical Name: 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin hydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

17-DMAG hydrochloride is a water-soluble analog of 17-AAG (Cat. No. 1515) and geldanamycin (Cat. No. 1368). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

Technical Data

M.Wt:
653.21
Formula:
C32H48N4O8.HCl
Solubility:
Soluble to 30 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at -20°C
CAS No:
467214-21-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the NIH, US Patent 6,890,917

Product Datasheets

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Citation for 17-DMAG hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for 17-DMAG hydrochloride include:

1 Citation: Showing 1 - 1

  1. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
    Authors: Young Et al.
    Mol Med  2015;11:113

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