Chemical Name: 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin hydrochloride
Biological Activity Water-soluble analog of 17-AAG (Cat. No. 1515) and geldanamycin (Cat. No. 1368). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).
Soluble to 30 mM in DMSO and to 10 mM in ethanol
Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Sold with the permission of the NIH, US Patent 6,890,917
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