Catalog Number: 2610
Alternate Names: NSC 707545
Chemical Name: 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin hydrochloride
Biological Activity
Water-soluble analog of 17-AAG (Cat. No. 1515) and geldanamycin (Cat. No. 1368). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).
Technical Data
  • M.Wt:
    653.21
  • Formula:
    C32H48N4O8.HCl
  • Solubility:
    Soluble to 30 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    467214-21-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the NIH, US Patent 6,890,917
Background References
  1. Inhibition of hsp90 compromises the DNA damage response to radiation.
    Dote, H et al.
    Cancer Res;66(18):9211-20.
  2. Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and fischer 344 rats.
    Egorin et al.
    Cancer Chemother.Pharmacol., 2002;49:7
  3. Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models.
    Smith et al.
    Cancer Chemother.Pharmacol., 2005;56:126
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 17-DMAG hydrochloride include:

1 Citations: Showing 1 - 1

  1. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
    Authors: Young Et al.
    Mol Med 2015;11:113

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