17-DMAG hydrochloride

Key Product Details

Product Description

17-DMAG hydrochloride is a water-soluble analog of 17-AAG (Cat. No. 1515) and geldanamycin (Cat. No. 1368). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI₅₀ values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

Licensing Information

Sold with the permission of the NIH, US Patent 6,890,917

Product Specifications for 17-DMAG hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 17-DMAG hydrochloride

The following data is based on the product molecular weight 653.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	5.10 mL	25.52 mL	51.03 mL
1.5 mM	1.02 mL	5.10 mL	10.21 mL
3 mM	0.51 mL	2.55 mL	5.10 mL
15 mM	0.10 mL	0.51 mL	1.02 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Smith Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. Cancer Chemother.Pharmacol. 2005 PMID: 15841378
• Dote Inhibition of Hsp90 compromises the DNA damage response to radiation. Cancer Res. 2006 PMID: 16982765
• Egorin Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and fischer 344 rats. Cancer Chemother.Pharmacol. 2002 PMID: 11855755

Product Documents for 17-DMAG hydrochloride