Chemical Name: 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin hydrochloride
Biological ActivityWater-soluble analog of 17-AAG (Cat. No. 1515) and geldanamycin (Cat. No. 1368). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of hsp90 compromises the DNA damage response to radiation.
Dote, H et al.
Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and fischer 344 rats.
Egorin et al.
Cancer Chemother.Pharmacol., 2002;49:7
Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models.
Smith et al.
Cancer Chemother.Pharmacol., 2005;56:126
Citation for 17-DMAG hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for 17-DMAG hydrochloride include:
1 Citation: Showing 1 - 1
A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
Authors: Young Et al.
Mol Med 2015;11:113
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