17-AAG

  ( 3 citations )    
Product Datasheet
Catalog Number:1515
Alternate Names:NSC 330507, 17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin
Chemical Name:17-Demethoxy-17-(2-propenylamino)geldanamycin
Product Details
Citations (3)
Reviews
Biological Activity
Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro.
Technical Data
  • M.Wt:
    585.7
  • Formula:
    C31H43N3O8
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    75747-14-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 17-AAG include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase.
    Authors: Truman Et al.
    J Proteomics  2015;112:285
  2. HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β.
    Authors: Fang Et al.
    Nat Commun  2014;5:5513
  3. Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab.
    Authors: Hughes Et al.
    Pharmaceuticals (Basel)  2012;5:674

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used 17-AAG?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee