17-AAG (CAS 75747-14-7): R&D Systems
Catalog Number: 1515
Alternate Names: NSC 330507, 17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin
Chemical Name: 17-Demethoxy-17-(2-propenylamino)geldanamycin
Biological Activity
Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro.
Technical Data
  • M.Wt:
    585.7
  • Formula:
    C31H43N3O8
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    75747-14-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.
    Hostein et al.
    Cancer Res., 2001;61:4003
  2. Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives.
    Schnur et al.
    J.Med.Chem., 1995;38:3806
  3. Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin.
    Yang et al.
    Cancer Res., 2001;61:4010
  4. Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range.
    Wang et al.
    J.Neurochem., 2011;117:703
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 17-AAG include:

1 Citations: Showing 1 - 1

  1. Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab.
    Authors: Hughes Et al.
    Pharmaceuticals (Basel) 2012;5:674

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