17-AAG

Catalog # Availability Size / Price Qty
1515/1
Cat.No. 1515 - 17-AAG | C31H43N3O8 | CAS No. 75747-14-7
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Description: Selective Hsp90 inhibitor
Alternative Names: NSC 330507, 17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin

Chemical Name: 17-Demethoxy-17-(2-propenylamino)geldanamycin

Purity: ≥98%

Product Details
Citations (4)
Reviews

Biological Activity

Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro.

Technical Data

M.Wt:
585.7
Formula:
C31H43N3O8
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
75747-14-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations for 17-AAG

The citations listed below are publications that use Tocris products. Selected citations for 17-AAG include:

4 Citations: Showing 1 - 4

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