Chemical Name: 17-Demethoxy-17-(2-propenylamino)geldanamycin
Biological ActivityInhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range.
Wang et al.
Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.
Hostein et al.
Cancer Res., 2001;61:4003
Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives.
Schnur et al.
Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin.
Yang et al.
Cancer Res., 2001;61:4010
Citations for 17-AAG
The citations listed below are publications that use Tocris products. Selected citations for 17-AAG include:
5 Citations: Showing 1 - 5
Hsp90 regulation of fibroblast activation in pulmonary fibrosis.
Authors: Sontake Et al.
JCI Insight 2017;2:e91454
Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase.
Authors: Truman Et al.
J Proteomics 2015;112:285
HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β.
Authors: Fang Et al.
Nat Commun 2014;5:5513
HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells.
Authors: Donnelly Et al.
EMBO J 2014;33:2374
Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with trastu.
Authors: Hughes Et al.
Pharmaceuticals (Basel) 2012;5:674
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