Chemical Name: 17-Demethoxy-17-(2-propenylamino)geldanamycin
Biological ActivityInhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range.
Wang et al.
Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.
Hostein et al.
Cancer Res., 2001;61:4003
Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives.
Schnur et al.
Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin.
Yang et al.
Cancer Res., 2001;61:4010
Citations for 17-AAG
The citations listed below are publications that use Tocris products. Selected citations for 17-AAG include:
4 Citations: Showing 1 - 4
Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase.
Authors: Truman Et al.
J Proteomics 2015;112:285
HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β.
Authors: Fang Et al.
Nat Commun 2014;5:5513
HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells.
Authors: Donnelly Et al.
EMBO J 2014;33:2374
Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab.
Authors: Hughes Et al.
Pharmaceuticals (Basel) 2012;5:674
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for 17-AAG
There are currently no reviews for this product. Be the first to review 17-AAG and earn rewards!
Have you used 17-AAG?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image