17-AAG

Tocris Bioscience | Catalog # 1515

Selective Hsp90 inhibitor
Tocris Bioscience

Key Product Details

Description

Selective Hsp90 inhibitor

Alternative Names

NSC 330507,17-(Allylamino)-17-demethoxygeldanamycin,Tanespimycin
View all HSP90 Inhibitors »

Product Description

17-AAG is an inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro.

Product Specifications for 17-AAG

Molecular Weight

585.70

Formula

C31H43N3O8

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

17-Demethoxy-17-(2-propenylamino)geldanamycin

CAS Number

75747-14-7

PubChem ID

6440175

InChI Key

AYUNIORJHRXIBJ-HTLBVUBBSA-N

SMILES

O=C1C(NCC=C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.86 10

Preparing Stock Solutions for 17-AAG

The following data is based on the product molecular weight 585.70.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.07 mL 85.37 mL 170.74 mL
0.5 mM 3.41 mL 17.07 mL 34.15 mL
1 mM 1.71 mL 8.54 mL 17.07 mL
5 mM 0.34 mL 1.71 mL 3.41 mL

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Product Documents for 17-AAG

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 17-AAG

For research use only

Customer Reviews for 17-AAG (2)

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  • Good Hsp90 blocker
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Primary hippocampal neurons
    Verified Customer | Posted 01/27/2023
    The drug was incubated at 100 nM to inhibit Hsp90.
  • HSP70 promoter/HSP90 inhibitor, strong data!
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Microglia
    Verified Customer | Posted 01/02/2021
    This is highly cytotoxic to human microglia at a high concentration (>100nM) from our cell viability data. We also confirmed this using imaging.
    I used it to down regulate the expression of HSP90. I checked using an antibody for HSP70 and showed upregulation of HSP70 with 10nM of 17-AAG. Easy to use product with informative data sheet. Stable in solution for months.
    17-AAG 1515

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