17-AAG

Catalog # Availability Size / Price Qty
1515/1
17-AAG | CAS No. 75747-14-7 | HSP90 Inhibitors
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Description: Selective Hsp90 inhibitor
Alternative Names: NSC 330507, 17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin

Chemical Name: 17-Demethoxy-17-(2-propenylamino)geldanamycin

Purity: ≥98%

Product Details
Citations (6)
Reviews (1)

Biological Activity

17-AAG is an inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro.

Technical Data

M.Wt:
585.7
Formula:
C31H43N3O8
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
75747-14-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for 17-AAG

The citations listed below are publications that use Tocris products. Selected citations for 17-AAG include:

6 Citations: Showing 1 - 6

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Reviews for 17-AAG

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HSP70 promoter/HSP90 inhibitor, strong data!
By Anonymous on 01/02/2021
Application: Species: Human

I used it to down regulate the expression of HSP90. I checked using an antibody for HSP70 and showed upregulation of HSP70 with 10nM of 17-AAG. Easy to use product with informative data sheet. Stable in solution for months.


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