Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin
(Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2
= 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo
. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro
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Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.
Hostein et al.
Cancer Res., 2001;61:4003
Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives.
Schnur et al.
Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin.
Yang et al.
Cancer Res., 2001;61:4010
Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range.
Wang et al.
The citations listed below are publications that use Tocris products. Selected citations for 17-AAG include:
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