Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (Kd
= 1.2 μ
M) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors. Demonstrates antiproliferative effect on breast cancer stem-like cells.
Soluble to 10 mM in DMSO
Desiccate at -20°C
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All Tocris products are intended for laboratory research use only.
Signal-transduction cascades as targets for therapeutic intervention by natural products.
Cardenas et al.
Trends Biotechnol., 1998;16:427
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.
Whitesell et al.
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanomycin.
Roe et al.
Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells.
Lee et al.
The citations listed below are publications that use Tocris products. Selected citations for Geldanamycin include:
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