Geldanamycin

  ( 3 citations )    
Product Datasheet
Catalog Number:1368
Chemical Name:9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate
Product Details
Citations (3)
Reviews
Biological Activity
Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors. Demonstrates antiproliferative effect on breast cancer stem-like cells.
Technical Data
  • M.Wt:
    560.64
  • Formula:
    C29H40N2O9
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    30562-34-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Geldanamycin include:

3 Citations: Showing 1 - 3
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  1. Hsp90 and hepatobiliary transformation during sea lamprey metamorphosis.
    Authors: Chung-Davidson Et al.
    Nucleic Acids Res  2015;15:47
  2. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
    Authors: Young Et al.
    BMC Dev Biol  2015;11:113
  3. Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damage.
    Authors: Barker Et al.
    Neuroscience  2006;34:1148

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