Geldanamycin

Catalog # Availability Size / Price Qty
1368/1
HSP90 Inhibitors Small Molecule
1 Image
Description: Selective Hsp90 inhibitor

Chemical Name: 9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate

Purity: ≥98%

Product Details
Citations (3)
Reviews (1)

Biological Activity

Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors. Demonstrates antiproliferative effect on breast cancer stem-like cells.

Technical Data

M.Wt:
560.64
Formula:
C29H40N2O9
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
30562-34-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Geldanamycin

The citations listed below are publications that use Tocris products. Selected citations for Geldanamycin include:

3 Citations: Showing 1 - 3

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Geldanamycin was used in resistance experiments
By Anonymous on 02/27/2019
Species: Human

Geldanamycin was used in resistance experiments. We investigated the Hsp90 family protein (HtpG) of the organism that makes GdA, S. hygroscopicus.


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