Biological ActivityInhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization.
(Modifications: Phe-2 = D-Phe, Pro-3 = D-Pro, Phe-4 = D-Phe, Pro-6 = D-Pro, Cyclized)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of another actin-related (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP.
Suetsugu et al.
How signaling proteins integrate multiple inputs: a comparison of N-WASP and cdk2.
Prehoda and Lim
Curr.Opin.Cell Biol., 2002;14:149
A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.
Peterson et al.
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