187-1, N-WASP inhibitor

Name: 187-1, N-WASP inhibitor
Brand: Tocris Bioscience
SKU: 2067

Tocris Bioscience | Catalog # 2067

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N-WASP inhibitor; inhibits actin assembly

Discontinued Product

2067 has been discontinued. View all Actin-related Products products.

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Background References
Product Documents
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Key Product Details

Description

N-WASP inhibitor; inhibits actin assembly

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Product Description

Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP₂)-stimulated actin assembly (IC₅₀ ~ 2 μM) but does not directly inhibit actin polymerization.

Product Specifications for 187-1, N-WASP inhibitor

Molecular Weight

1784.13

Formula

C₉₆H₁₂₂N₁₈O₁₆

Storage

Desiccate at -20°C

CAS Number

380488-27-7

PubChem ID

44405676

InChI Key

PHTIQAVQWWOKNF-RNEDXEELSA-N

SMILES

NCCCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CC2=CC=CC=C2)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Prehoda and Lim How signaling proteins integrate multiple inputs: a comparison of N-WASP and cdk2. Curr.Opin.Cell Biol. 2002 PMID: 11891112
Peterson A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc.Natl.Acad.Sci.USA
Suetsugu Identification of another actin-related (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J.Biol.Chem. 2001 PMID: 11432863

Product Documents for 187-1, N-WASP inhibitor

Certificate of Analysis

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Product Specific Notices for 187-1, N-WASP inhibitor

For research use only

Related Research Areas

Adhesion Molecules on Endothelial Cells

Epithelial Cell Polarity

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