187-1, N-WASP inhibitor

Discontinued Product

2067 has been discontinued.
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187-1, N-WASP inhibitor
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Description: N-WASP inhibitor; inhibits actin assembly
Product Details

Biological Activity

Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization.

Technical Data


(Modifications: Phe-2 = D-Phe, Pro-3 = D-Pro, Phe-4 = D-Phe, Pro-6 = D-Pro, Cyclized)

Soluble to 2 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of another actin-related (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP.
    Suetsugu et al.
    J.Biol.Chem., 2001;276:33175
  2. How signaling proteins integrate multiple inputs: a comparison of N-WASP and cdk2.
    Prehoda and Lim
    Curr.Opin.Cell Biol., 2002;14:149
  3. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.
    Peterson et al.
    Proc.Natl.Acad.Sci.USA, 2001;98:10624

Product Datasheets

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