Catalog Number: 2067
Biological Activity
Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Phe-2 = D-Phe, Pro-3 = D-Pro, Phe-4 = D-Phe, Pro-6 = D-Pro, Cyclized)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of another actin-related (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP.
    Suetsugu et al.
    J.Biol.Chem., 2001;276:33175
  2. How signaling proteins integrate multiple inputs: a comparison of N-WASP and cdk2.
    Prehoda and Lim
    Curr.Opin.Cell Biol., 2002;14:149
  3. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.
    Peterson et al.
    Proc.Natl.Acad.Sci.USA, 2001;98:10624
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