1A-116

Catalog # Availability Size / Price Qty
6701/10
6701/50
Rho GTPase Inhibitors Small Molecule
1 Image
Description: Rac1 inhibitor; blocks Rac1-P-Rex1 interaction

Chemical Name: N-(3,5-Dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]guanidine

Purity: ≥98%

Product Details
Reviews

Biological Activity

Rac1 inhibitor. Reduces intracellular Rac1-GTP levels and blocks Rac1-P-Rex1 interaction in vitro. Exhibits no effect on GTPase activity of closely related Cdc42. Displays antiproliferative, anti-invasive and pro-apoptotic activity in several cancer cell lines. Exhibits antimetastatic activity in vivo. Also restores antiproliferative effects of Tamoxifen (Cat. No. 6342) in resistant breast cancer cell.

Technical Data

M.Wt:
307.31
Formula:
C16H16F3N3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1430208-73-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Romikin S.A.

Product Datasheets

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