2',3'-cGAMP sodium salt

Name: 2',3'-cGAMP sodium salt
Brand: Tocris Bioscience
SKU: 5945
Price: 384 USD
Availability: InStock

Tocris Bioscience | Catalog # 5945

Submit a review

Citations (3)

Product Documents

Endogenous high affinity STING agonist

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Endogenous high affinity STING agonist

Product Description

2',3'-cGAMP sodium salt is a endogenous high affinity STING agonist (K_d values are 3.79 and 120 nM for human and rat STING, respectively). Induces repolarization of M2 macrophages in vitro.

This product is sold in units of 359μg, equivalent to 0.5μmol.

Product Specifications for 2',3'-cGAMP sodium salt

Molecular Weight

718.37

Formula

C₂₀H₂₂N₁₀Na₂O₁₃P₂

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt

CAS Number

2734858-36-5

PubChem ID

71563406

InChI Key

XRILCFTWUCUKJR-INFSMZHSSA-N

SMILES

[H][C@]12COP(O[C@]3([C@H]([C@H](N4C=NC5=C(N=CN=C45)N)O[C@@]3(COP(O[C@@]([C@H](N6C=NC7=C6N=C(NC7=O)N)O1)([C@@H]2O)[H])(O[Na])=O)[H])O)[H])(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	35.92	50

Preparing Stock Solutions for 2',3'-cGAMP sodium salt

The following data is based on the product molecular weight 718.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.78 mL	13.92 mL	27.84 mL
2.5 mM	0.56 mL	2.78 mL	5.57 mL
5 mM	0.28 mL	1.39 mL	2.78 mL
25 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Downey DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS One 2014 PMID: 24940883
Zhang Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci.Rep. 2015 PMID: 26669264
Zhang Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol.Cell. 2013 PMID: 23747010

Product Documents for 2',3'-cGAMP sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for 2',3'-cGAMP sodium salt

For research use only

Citations for 2',3'-cGAMP sodium salt

Customer Reviews for 2',3'-cGAMP sodium salt

There are currently no reviews for this product. Be the first to review 2',3'-cGAMP sodium salt and earn rewards!

Have you used 2',3'-cGAMP sodium salt?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image