2-Chloro-N6-cyclopentyladenosine

  ( 10 citations )    
Product Datasheet
Catalog Number:1705
Alternate Names:CCPA
Chemical Name:2-Chloro-N-cyclopentyladenosine
Product Details
Citations (10)
Supplemental Products
Reviews
Biological Activity
Potent and selective adenosine A1 receptor agonist (Ki values are 0.8, 2300 and 42 nM for human A1, A2A and A3 receptors respectively; EC50 = 18800 nM for hA2B). Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    369.81
  • Formula:
    C15H20ClN5O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    37739-05-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for 2-Chloro-N6-cyclopentyladenosine include:

10 Citations: Showing 1 - 10
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  1. Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts.
    Authors: Goldman Et al.
    BMC Pharmacol Toxicol  2013;53:297
  2. Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling.
    Authors: Loram Et al.
    Brain Behav Immun  2013;33:112
  3. Opiate-induced changes in brain adenosine levels and narcotic drug responses.
    Authors: Wu Et al.
    J Neurosci  2013;228:235
  4. Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.
    Authors: Park Et al.
    Kidney Int  2012;82:878
  5. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.
    Authors: Hamby Et al.
    Neuroscience  2012;32:14489
  6. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.
    Authors: Crawford Et al.
    Cell Calcium  2012;32:13100
  7. Adenosine receptor signaling modulates permeability of the blood-brain barrier.
    Authors: Carman Et al.
    J Neurosci  2011;31:13272
  8. Adenosine-induced activation of esophageal nociceptors.
    Authors: Ru Et al.
    Am J Physiol Gastrointest Liver Physiol  2011;300:G485
  9. Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor.
    Authors: Keene Et al.
    Biochem Pharmacol  2010;80:188
  10. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine.
    Authors: Long Et al.
    J Neurosci  2010;335:781

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VersaClone cDNA Plasmids
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Human Adenosine A1 R (NP_000665) VersaClone cDNA

RDC0213
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Mouse Adenosine A1 R (NP_000665) VersaClone cDNA

RDC2041
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