Catalog Number: 1705
Alternate Names: CCPA
Chemical Name: 2-Chloro-N-cyclopentyladenosine
Biological Activity
Potent and selective adenosine A1 receptor agonist (Ki values are 0.8, 2300 and 42 nM for human A1, A2A and A3 receptors respectively; EC50 = 18800 nM for hA2B). Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    369.81
  • Formula:
    C15H20ClN5O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    37739-05-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Adenosine receptors and their ligands.
    Klot
    Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
  2. Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
    Concas et al.
    J.Pharmacol.Exp.Ther., 1993;267:844
  3. Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine.
    Monopoli et al.
    Arzneimittelforschung, 1994;44:1305
  4. 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors.
    Lohse et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1988;337:687
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 2-Chloro-N6-cyclopentyladenosine include:

7 Citations: Showing 1 - 7
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  1. Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts.
    Authors: Goldman Et al.
    BMC Pharmacol Toxicol 2013;53:297
  2. Opiate-induced changes in brain adenosine levels and narcotic drug responses.
    Authors: Wu Et al.
    J Neurosci 2013;228:235
  3. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.
    Authors: Hamby Et al.
    Neuroscience 2012;32:14489
  4. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.
    Authors: Crawford Et al.
    Cell Calcium 2012;32:13100
  5. Adenosine-induced activation of esophageal nociceptors.
    Authors: Ru Et al.
    Am J Physiol Gastrointest Liver Physiol 2011;300:G485
  6. Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor.
    Authors: Keene Et al.
    Biochem Pharmacol 2010;80:188
  7. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine.
    Authors: Long Et al.
    J Neurosci 2010;335:781

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