2-Chloro-N⁶-cyclopentyladenosine

Key Product Details

Product Description

2-Chloro-N⁶-cyclopentyladenosine is a potent and selective adenosine A₁ receptor agonist (K_i values are 0.8, 2300 and 42 nM for human A₁, A_2A and A₃ receptors respectively; EC₅₀ = 18800 nM for hA_2B). Centrally active following systemic administration in vivo.

Product Specifications for 2-Chloro-N⁶-cyclopentyladenosine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 2-Chloro-N⁶-cyclopentyladenosine

The following data is based on the product molecular weight 369.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.70 mL	13.52 mL	27.04 mL
5 mM	0.54 mL	2.70 mL	5.41 mL
10 mM	0.27 mL	1.35 mL	2.70 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

• Monopoli Pharmacology of the highly selective A₁ adenosine receptor agonist 2-chloro-N⁶-cyclopentyladenosine. Arzneimittelforschung 1994 PMID: 7848348
• Klotz Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 2000 PMID: 11111832
• Lohse 2-Chloro-N⁶-cyclopentyladenosine: a highly selective agonist at A₁ adenosine receptors. Naunyn Schmiedebergs Arch.Pharmacol. 1988 PMID: 3216901
• Concas Anticonvulsant doses of 2-chloro-N⁶-cyclopentyladenosine, an adenosine A₁ receptor agonist, reduce GABAergic transmission in different areas of the mouse brain. J.Pharmacol.Exp.Ther. 1993 PMID: 8246158

Product Documents for 2-Chloro-N⁶-cyclopentyladenosine