Catalog Number: 1104
Chemical Name: 1-[2-Chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide
Biological Activity
High affinity and extremely selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively. Exhibits high selectivity over the Na+-independent adenosine transporter.
Technical Data
  • M.Wt:
    544.74
  • Formula:
    C18H18ClIN6O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    163042-96-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the NIH, US Patent 08/091,109
Background References
  1. Adenosine A3 receptors: novel ligands and paradoxical effects.
    Jacobson
    TiPS, 1998;19:184
  2. 2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors.
    Kim et al.
    J.Med.Chem., 1994;37:3614
  3. Hemodynamic effects of histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats.
    Schaick et al.
    Eur.J.Pharmacol., 1996;308:311
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 2-Cl-IB-MECA include:

12 Citations: Showing 1 - 10
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  1. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    Sci Rep 2015;9:409
  2. An adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-κB signaling pathway.
    Authors: Ren Et al.
    J Neurosci 2015;5:9047
  3. Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model.
    Authors: Iannone Et al.
    EMBO Rep 2014;4:172
  4. Pulsed electromagnetic fields increased the anti-inflammatory effect of A2A and A3 adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts.
    Authors: Vincenzi Et al.
    PLoS One 2013;8:e65561
  5. Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes.
    Authors: Corriden Et al.
    Biochim Biophys Acta 2013;14:726
  6. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
    Authors: Kan Et al.
    J Virol 2012;86:10338
  7. Adoptive immunotherapy with Cl-IB-MECA-treated CD8+ T cells reduces melanoma growth in mice.
    Authors: Montinaro Et al.
    PLoS One 2012;7:e45401
  8. CXCL16 orchestrates adenosine A3 receptor and MCP-1/CCL2 activity to protect neurons from excitotoxic cell death in the CNS.
    Authors: Rosito Et al.
    Neoplasia 2012;32:3154
  9. NK1.1 cells and CD8 T cells mediate the antitumor activity of Cl-IB-MECA in a mouse melanoma model.
    Authors: Morello Et al.
    Am J Cancer Res 2011;13:365
  10. Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives.
    Authors: Bhanu Et al.
    J Pharmacol Exp Ther 2008;1782:504
  11. Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes.
    Authors: Germack and Dickenson
    Br J Pharmacol 2004;141:329
  12. Alteration of the purinergic modulation of enteric neurotransmission in the mouse ileum during chronic intestinal inflammation.
    Authors: Man Et al.
    Br J Pharmacol 2003;139:172
Expand to show all 12 Citations
Average Rating: 4 (Based on 1 review)

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