2-Iodomelatonin

Key Product Details

Product Description

2-Iodomelatonin is a potent melatonin agonist (pK_i values are 10.55 and 9.87 at human recombinant MT₁ and MT₂ receptors respectively). 2-[¹²⁵I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

Product Specifications for 2-Iodomelatonin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 2-Iodomelatonin

The following data is based on the product molecular weight 358.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.96 mL	27.92 mL
5 mM	0.56 mL	2.79 mL	5.58 mL
10 mM	0.28 mL	1.40 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Dubocovich and Takahashi Use of 2-[¹²⁵l]-iodomelatonin to characterize melatonin sites in chicken retina. Proc.Natl.Acad.Sci.U.S.A. 1987 PMID: 3035559
• Suiciak Quantitative pharmacological analysis of 2-[¹²⁵l]-iodomelatonin binding sites in discrete areas of the chicken brain. J.Neurosci. 1991 PMID: 1652626
• Browning Pharmacological characterization of human recombinant melatonin mt₁ and MT₂ receptors. Br.J.Pharmacol. 2000 PMID: 10696085

Product Documents for 2-Iodomelatonin