Catalog Number: 0737
Chemical Name: N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide
Biological Activity
Potent melatonin agonist (pKi values are 10.55 and 9.87 at human recombinant MT1 and MT2 receptors respectively). 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.
Technical Data
  • M.Wt:
    358.18
  • Formula:
    C13H15IN2O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    93515-00-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors.
    Browning et al.
    Br.J.Pharmacol., 2000;129:877
  2. Use of 2-[125l]-iodomelatonin to characterize melatonin sites in chicken retina.
    Dubocovich and Takahashi
    Proc.Natl.Acad.Sci.U.S.A., 1987;84:3916
  3. Quantitative pharmacological analysis of 2-[125l]-iodomelatonin binding sites in discrete areas of the chicken brain.
    Suiciak et al.
    J.Neurosci., 1991;11:2855
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 2-Iodomelatonin include:

2 Citations: Showing 1 - 2
Filter your results:

  1. Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2.
    Authors: Calamini Et al.
    Biochem J 2008;413:81
  2. Identification of the melatonin-binding site MT3 as the quinone reductase 2.
    Authors: Nosjean Et al.
    J Biol Chem 2000;275:31311

Have you used 2-Iodomelatonin?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information