Catalog Number: 0737
Chemical Name: N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide
Biological Activity
Potent melatonin agonist (pKi values are 10.55 and 9.87 at human recombinant MT1 and MT2 receptors respectively). 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors.
    Browning et al.
    Br.J.Pharmacol., 2000;129:877
  2. Use of 2-[125l]-iodomelatonin to characterize melatonin sites in chicken retina.
    Dubocovich and Takahashi
    Proc.Natl.Acad.Sci.U.S.A., 1987;84:3916
  3. Quantitative pharmacological analysis of 2-[125l]-iodomelatonin binding sites in discrete areas of the chicken brain.
    Suiciak et al.
    J.Neurosci., 1991;11:2855

The citations listed below are publications that use Tocris products. Selected citations for 2-Iodomelatonin include:

Showing Results 1 - 2 of 2

  1. Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2.
    Authors: Calamini Et al.
    Biochem J
  2. Identification of the melatonin-binding site MT3 as the quinone reductase 2.
    Authors: Nosjean Et al.
    J Biol Chem
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