Chemical Name: N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide
Biological ActivityPotent melatonin agonist (pKi values are 10.55 and 9.87 at human recombinant MT1 and MT2 receptors respectively). 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors.
Browning et al.
Use of 2-[125l]-iodomelatonin to characterize melatonin sites in chicken retina.
Dubocovich and Takahashi
Quantitative pharmacological analysis of 2-[125l]-iodomelatonin binding sites in discrete areas of the chicken brain.
Suiciak et al.
Citations for 2-Iodomelatonin
The citations listed below are publications that use Tocris products. Selected citations for 2-Iodomelatonin include:
3 Citations: Showing 1 - 3
Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats.
Authors: Hou Et al.
Front Cell Neurosci 2017;11:98
Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2.
Authors: Calamini Et al.
Biochem J 2008;413:81
Identification of the melatonin-binding site MT3 as the quinone reductase 2.
Authors: Nosjean Et al.
J Biol Chem 2000;275:31311
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