2'-MeCCPA

Key Product Details

Product Description

2'-MeCCPA is a potent and highly selective agonist at A₁ adenosine receptors (K_i values are 3.3, 9580, 37600 and 1150 nM for human recombinant A₁, A_2A, A_2B and A₃ receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC₅₀ value of 13.1 nM.

Product Specifications for 2'-MeCCPA

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 2'-MeCCPA

The following data is based on the product molecular weight 383.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.42 mL	52.11 mL	104.21 mL
1.25 mM	2.08 mL	10.42 mL	20.84 mL
2.5 mM	1.04 mL	5.21 mL	10.42 mL
12.5 mM	0.21 mL	1.04 mL	2.08 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Cappellacci Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. J.Med.Chem. 2005 PMID: 15743197
• Franchetti 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. J.Med.Chem. 1998 PMID: 9572897

Product Documents for 2'-MeCCPA