2-Phenylmelatonin

Tocris Bioscience | Catalog # 0680

Potent melatonin agonist
Tocris Bioscience

Key Product Details

Description

Potent melatonin agonist
View all Melatonin (MT) Receptor Agonists »

Product Description

2-Phenylmelatonin is a highly potent melatonin agonist; displays higher affinity and greater potency than melatonin itself. The EC50 values for G protein activation in MT1 and MT2-transfected cells are 65 and 58 pM respectively.

Product Specifications for 2-Phenylmelatonin

Molecular Weight

308.38

Formula

C19H20N2O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-(5-Methoxy-2-phenylindol-3-yl)ethyl]acetamide

CAS Number

151889-03-1

PubChem ID

4018512

InChI Key

OFCLARYYBGKCHN-UHFFFAOYSA-N

SMILES

COC1=CC=C2NC(=C(CCNC(C)=O)C2=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.84 100
Ethanol 30.84 100

Preparing Stock Solutions for 2-Phenylmelatonin

The following data is based on the product molecular weight 308.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.21 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for 2-Phenylmelatonin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 2-Phenylmelatonin

For research use only

Citations for 2-Phenylmelatonin

Customer Reviews for 2-Phenylmelatonin (1)

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  • Highly recommended for in vitro stabilization and crystallization of melatonin receptors
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/11/2022
    Dissolves well in DMSO
    After trying many other melatonin receptor ligands, this has become our gold standard for stabilizing MT1 and MT2 melatonin GPCRs for in vitro studies. Given its high potency, relatively low micromolar concentrations are sufficient to achieve the desired effect. We found that it sufficiently stabilizes MTRs for crystallization purposes. Additionally, in cell based GPCR activity assays, it is able to achieve an efficacy as high as, or higher, than the endogenous ligand melatonin. Highly recommended if you value maximum stabilization and/or efficacy

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