Chemical Name: (3β)-Cholest-5-ene-3,20-diol
Biological Activity20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein; binds at a site distinct from the canonical cyclopamine binding site. Activates Hedgehog (Hh) signaling (EC50 ~ 3μM for induction of Hh reporter gene transcription in in NIH 3T3 cells). Induces Smo accumulation in primary cilia; also exhibits osteogenic activity and activates the liver X receptor (LXR).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Oxysterols are allosteric activators of the oncoprotein Smoothened.
Nachtergaele S, Mydock LK, Krishnan K et al.
Nat Chem Biol
Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells
Dwyer et al.
Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling.
Nedelcu et al.
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