20(S)-Hydroxycholesterol

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4474/10
20(S)-Hydroxycholesterol | CAS No. 516-72-3 | Hedgehog Signaling Activators
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Description: Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation

Chemical Name: (3β)-Cholest-5-ene-3,20-diol

Purity: ≥95%

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Biological Activity

Allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein; binds at a site distinct from the canonical cyclopamine binding site. Activates Hedgehog (Hh) signaling (EC50 ~ 3μM for induction of Hh reporter gene transcription in in NIH 3T3 cells). Induces Smo accumulation in primary cilia; also exhibits osteogenic activity and activates the liver X receptor (LXR).

Technical Data

M.Wt:
402.65
Formula:
C27H46O2
Solubility:
Soluble to 100 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
516-72-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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