Allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein; binds at a site distinct from the canonical cyclopamine
binding site. Activates Hedgehog (Hh) signaling (EC50
M for induction of Hh reporter gene transcription in in NIH 3T3 cells). Induces Smo accumulation in primary cilia; also exhibits osteogenic activity and activates the liver X receptor (LXR).
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Oxysterols are allosteric activators of the oncoprotein Smoothened.
Nachtergaele et al.
Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling.
Nedelcu et al.
Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells
Dwyer et al.