3',2'-cGAMP sodium salt

Key Product Details

Product Description

3',2'-cGAMP sodium salt is a second messenger in the antiviral immune response in Drosophila melanogaster and in bacteria. 3',2'-cGAMP is selective for Drosophila stimulator of interferon genes (dSTING); induces expression of STING and STING-related genes. After injection of drosophila C virus dsRNA into Drosophila, 3',2'-cGAMP activates STING-dependent antiviral immunity in vivo, reduces viral RNA load and increases survival. In bacteria 3',2'-cGAMP activates DNA degradation of AsCap5 and LlCap5.

Product Specifications for 3',2'-cGAMP sodium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 3',2'-cGAMP sodium salt

The following data is based on the product molecular weight 718.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.92 mL	69.60 mL	139.20 mL
0.5 mM	2.78 mL	13.92 mL	27.84 mL
1 mM	1.39 mL	6.96 mL	13.92 mL
5 mM	0.28 mL	1.39 mL	2.78 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Fatma Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3',2'-cGAMP as the second messenger. Nat.Commun. 2021 PMID: 34737303
• Slavik cGAS-like receptors sense RNA and control 3',2'-cGAMP signalling in Drosophila. Nature 2021 PMID: 34261127

Product Documents for 3',2'-cGAMP sodium salt