3'-Phosphoadenosine-5'-phosphosulfate (PAPS) is the universal sulfur donor for sulfotransferases. It is synthesized from ATP through two steps. In the first step, one ATP molecule is converted to adenosine-5'-phosphosulfate (APS) by ATP sulfurylase and pyrophosphate (PPi) is generated as a byproduct. In the second step, the APS is converted to PAPS by APS kinase and ADP is generated as a byproduct. To drive the reaction forward, the pyrophosphate can be further degraded to phosphate (Pi) by inorganic pyrophosphatase to eliminate feedback inhibition, and the ADP can be converted back to ATP using pyruvate kinase.
Citations for 3'-Phosphoadenosine-5'-phosphosulfate
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Identification of Galeterone and Abiraterone as Inhibitors of Dehydroepiandrosterone Sulfonation Catalyzed by Human Hepatic Cytosol, SULT2A1, SULT2B1b, and SULT1E1
Authors: CKY Yip, S Bansal, SY Wong, AJ Lau
Drug Metab. Dispos., 2018;0(0):. 2018
Expression, purification and characterization of human cytosolic sulfotransferase (SULT) 1C4
Authors: AL Guidry, ZE Tibbs, M Runge-Morr, CN Falany
Horm Mol Biol Clin Investig, 2017;0(0):. 2017
Detection of specific glycosaminoglycans and glycan epitopes by in vitro sulfation using recombinant sulfotransferases.
Authors: Wu ZL, Prather B, Ethen CM
Glycobiology, 2011;21(5):625-33. 2011
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