Chemical Name: 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide
Biological ActivityFree fatty acid receptor FFA2 agonist (pEC50 = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.
Smith et al.
Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3.
Milligan et al.
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