Chemical Name: 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide
Biological ActivityFree fatty acid receptor FFA2 agonist (pEC50 = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.
Smith et al.
Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3.
Milligan et al.
Citation for 4-CMTB
The citations listed below are publications that use Tocris products. Selected citations for 4-CMTB include:
1 Citation: Showing 1 - 1
Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells
Authors: Marinelli Et al.
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