Catalog Number: 4234
Chemical Name: 4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
Biological Activity
Allosteric agonist at α7 nAChR. Binds at a separate site and exhibits more efficacious receptor agonism compared to acetylcholine (Cat. No. 2809), displays 8-fold lower EC50 value and 45-fold larger maximal response.
Technical Data
  • M.Wt:
    405.31
  • Formula:
    C18H17BrN2O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    360791-49-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
    Gill et al.
    Proc.Natl.Acad.Sci.U.S.A., 2011;108:5867
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 4BP-TQS include:

1 Citations: Showing 1 - 1

  1. Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor.
    Authors: Zhang Et al.
    Proc Natl Acad Sci U S A 2015;10:e0137588

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