4E1RCat

  ( 1 citations )    
Product Datasheet
Catalog Number:4215
Chemical Name:4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid
Product Details
Citations (1)
Reviews
Biological Activity
Inhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50 ~4 μM). Exhibits chemosensitizing properties.
Technical Data
  • M.Wt:
    478.45
  • Formula:
    C28H18N2O6
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    328998-25-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 4E1RCat include:

1 Citations: Showing 1 - 1

  1. Regulation of cardiac expression of the diabetic marker microRNA miR-29.
    Authors: Arnold Et al.
    PLoS One  2014;9:e103284

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