Chemical Name: 4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid
Biological Activity4E1RCat is an inhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50 ~4 μM). Exhibits chemosensitizing properties.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.
Cencic et al.
Citation for 4E1RCat
The citations listed below are publications that use Tocris products. Selected citations for 4E1RCat include:
1 Citation: Showing 1 - 1
Regulation of cardiac expression of the diabetic marker microRNA miR-29.
Authors: Arnold Et al.
PLoS One 2014;9:e103284
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