4E1RCat

Catalog # Availability Size / Price Qty
4215/10
4215/50
4E1RCat | CAS No. 328998-25-0 | Protein-synthesizing GTPase Compounds
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Description: Inhibits eIF4F subunit interaction; inhibits protein translation

Chemical Name: 4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Inhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50 ~4 μM). Exhibits chemosensitizing properties.

Technical Data

M.Wt:
478.45
Formula:
C28H18N2O6
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
328998-25-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.
    Cencic et al.
    Proc.Natl.Acad.Sci.USA, 2010;108:1046

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Citation for 4E1RCat

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