Chemical Name: 4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid
Biological ActivityInhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50 ~4 μM). Exhibits chemosensitizing properties.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.
Cencic et al.
Citation for 4E1RCat
The citations listed below are publications that use Tocris products. Selected citations for 4E1RCat include:
1 Citation: Showing 1 - 1
Regulation of cardiac expression of the diabetic marker microRNA miR-29.
Authors: Arnold Et al.
PLoS One 2014;9:e103284
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for 4E1RCat
There are currently no reviews for this product. Be the first to review 4E1RCat and earn rewards!
Have you used 4E1RCat?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image