Inhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50
M). Exhibits chemosensitizing properties.
Soluble to 50 mM in DMSO
Store at -20°C
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Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.
Cencic et al.
The citations listed below are publications that use Tocris products. Selected citations for 4E1RCat include:
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