Chemical Name: α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid
Biological ActivityInhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Autism-related deficits via dysregulated eIF4E-dependent translational control.
Gkogkas C, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill D, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille J, Sonenberg N
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.
Moerke et al.
Citation for 4EGI-1
The citations listed below are publications that use Tocris products. Selected citations for 4EGI-1 include:
1 Citation: Showing 1 - 1
Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming.
Authors: Riz Et al.
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