Catalog # Availability Size / Price Qty
4EGI-1 | CAS No. 315706-13-9 | Protein-synthesizing GTPase Compounds
1 Image
Description: Inhibits eIF4E:eIF4G subunit interaction

Chemical Name: α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

4EGI-1 is an inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Autism-related deficits via dysregulated eIF4E-dependent translational control.
    Gkogkas C, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill D, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille J, Sonenberg N
    Nature, 2013;493(7432):371-7.
  2. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.
    Moerke et al.
    Cell, 2007;128:257

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Citation for 4EGI-1

The citations listed below are publications that use Tocris products. Selected citations for 4EGI-1 include:

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