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4EGI-1

Catalog #: 4800
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4EGI-1 | CAS No. 315706-13-9 | Protein-synthesizing GTPase Compounds
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Description: Inhibits eIF4E:eIF4G subunit interaction

Chemical Name: α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

4EGI-1 is an inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.

Technical Data

M.Wt:
451.28
Formula:
C18H12Cl2N4O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
315706-13-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Autism-related deficits via dysregulated eIF4E-dependent translational control.
    Gkogkas C, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill D, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille J, Sonenberg N
    Nature, 2013;493(7432):371-7.
  2. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.
    Moerke et al.
    Cell, 2007;128:257

Product Datasheets

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Citation for 4EGI-1

The citations listed below are publications that use Tocris products. Selected citations for 4EGI-1 include:

1 Citation: Showing 1 - 1

  1. Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming.
    Authors: Riz Et al.
    Oncotarget  2016;7:66360

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