4EGI-1

Tocris Bioscience | Catalog # 4800

Inhibits eIF4E:eIF4G subunit interaction
Tocris Bioscience

Key Product Details

Description

Inhibits eIF4E:eIF4G subunit interaction
View all Protein-synthesizing GTPase Compounds »

Product Description

4EGI-1 is an inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.

Product Specifications for 4EGI-1

Molecular Weight

451.28

Formula

C18H12Cl2N4O4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid

CAS Number

315706-13-9

PubChem ID

6911989

InChI Key

KFRKRECSIYXARE-HMAPJEAMSA-N

SMILES

OC(=O)C(\CC1=CC=CC=C1[N+]([O-])=O)=N/NC1=NC(=CS1)C1=CC(Cl)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.13 100

Preparing Stock Solutions for 4EGI-1

The following data is based on the product molecular weight 451.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.08 mL 22.16 mL
5 mM 0.44 mL 2.22 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

Product Documents for 4EGI-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 4EGI-1

For research use only

Customer Reviews for 4EGI-1 (1)

4 out of 5
1 Customer Rating
5 Stars
0%
4 Stars
100%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used 4EGI-1?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • (4EGI-1, 50 µM)
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: LP-1 cell line
    Verified Customer | Posted 12/11/2019
    Cells were treated with MG-132 (15 µM) for 18 hours in the absence or presence of an eIF4E/eIF4G interaction inhibitor (4EGI-1, 50 µM) or an MNK inhibitor (CGP57380, 10 μM).
    4EGI-1 4800

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All