Catalog Number: 0523
Chemical Name: 4-(4-Fluorobenzoyl)-1-(4-phenylbutyl)piperidine oxalate
Biological Activity
A selective 5-HT2A antagonist with almost as high affinity (Ki = 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki = 620 nM).
Technical Data
  • M.Wt:
    429.49
  • Formula:
    C22H26FNO.C2H2O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    144734-36-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ketanserin analogues - structure affinity relationships of 5HT2 and 5HT1C serotonin receptor binding.
    Herndon et al.
    J.Med.Chem., 1992;35:4903
  2. Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
    Hagberg et al.
    Neurochem.Int., 1998;32:153
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 4F 4PP oxalate include:

1 Citations: Showing 1 - 1

  1. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci 2015;35:9580

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