Catalog Number: 0908
Alternate Names: R 41 468
Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate
Biological Activity
Selective 5-HT2A serotonin receptor antagonist; can also be used to discriminate between 5-HT1D and 5-HT1B receptor subtypes.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differences in the effects of ketanserin and GR 127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein.
    Razzaque et al.
    Eur.J.Pharmacol., 1995;283:199
  2. Ketanserin and ritanserin discriminate between recombinant human 5-HT1Dα and 5-HT1Dβ receptor subtypes.
    Zgombick et al.
    Eur.J.Pharmacol., 1995;291:9
  3. Vascular effects of ketanserin (R41 468), a novel antagonist of 5-HT2 serotonergic receptors.
    Van Nueten et al.
    J.Pharmacol.Exp.Ther., 1981;218:217
  4. Receptor binding profile of R41 468, a novel antagonist at 5-HT2 receptors.
    Leyson et al.
    Life Sci., 1981;28:1015

The citations listed below are publications that use Tocris products. Selected citations for Ketanserin tartrate include:

Showing Results 1 - 10 of 12

  1. Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors.
    Authors: Jiang Et al.
    Br J Pharmacol
  2. Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens.
    Authors: Kasper Et al.
  3. Behavioral and neurochemical changes in mesostriatal dopaminergic regions of the rat after chronic administration of the cannabinoid receptor agonist WIN55,212-2.
    Authors: Fanarioti Et al.
  4. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass.
    Authors: Ratner Et al.
  5. Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension.
    Authors: Morecroft Et al.
    Cereb Cortex
  6. Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production.
    Authors: Wood Et al.
    J Neurosci
  7. Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster.
    Authors: Johnson Et al.
  8. Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation.
    Authors: Kleinbongard Et al.
    Circ Res
  9. In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
    Authors: Morecroft Et al.
    Int J Neuropsychopharmacol
  10. Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses.
    Authors: Watakabe Et al.
    Br J Pharmacol
  11. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
    Authors: González-Maeso Et al.
    Mol Ther
  12. 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor.
    Authors: Morecroft Et al.
    Obesity (Silver Spring)
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