Ketanserin tartrate (CAS 83846-83-7): R&D Systems
Catalog Number: 0908
Alternate Names: R 41 468
Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate
Biological Activity
Selective 5-HT2A serotonin receptor antagonist; can also be used to discriminate between 5-HT1D and 5-HT1B receptor subtypes.
Technical Data
  • M.Wt:
    545.52
  • Formula:
    C22H22FN3O3.C4H6O6
  • Solubility:
    Soluble to 10 mM in water
  • Purity:
    >97%
  • Storage:
    Store at RT
  • CAS No:
    83846-83-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differences in the effects of ketanserin and GR 127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein.
    Razzaque et al.
    Eur.J.Pharmacol., 1995;283:199
  2. Ketanserin and ritanserin discriminate between recombinant human 5-HT1Dα and 5-HT1Dβ receptor subtypes.
    Zgombick et al.
    Eur.J.Pharmacol., 1995;291:9
  3. Vascular effects of ketanserin (R41 468), a novel antagonist of 5-HT2 serotonergic receptors.
    Van Nueten et al.
    J.Pharmacol.Exp.Ther., 1981;218:217
  4. Receptor binding profile of R41 468, a novel antagonist at 5-HT2 receptors.
    Leyson et al.
    Life Sci., 1981;28:1015
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ketanserin tartrate include:

13 Citations: Showing 1 - 10
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  1. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
    Authors: Hirono
    Neuropharmacology 2017;118:79
  2. Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors.
    Authors: Jiang Et al.
    Br J Pharmacol 2015;89:342
  3. Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens.
    Authors: Kasper Et al.
    Neuropharmacology 2015;69:78
  4. Behavioral and neurochemical changes in mesostriatal dopaminergic regions of the rat after chronic administration of the cannabinoid receptor agonist WIN55,212-2.
    Authors: Fanarioti Et al.
    Synapse 2015;18
  5. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass.
    Authors: Ratner Et al.
    Neuron 2012;20:2133
  6. Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension.
    Authors: Morecroft Et al.
    Cereb Cortex 2012;20:1516
  7. Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production.
    Authors: Wood Et al.
    J Neurosci 2011;31:13808
  8. Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster.
    Authors: Johnson Et al.
    Neuroscience 2011;192:372
  9. Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation.
    Authors: Kleinbongard Et al.
    Circ Res 2011;108:344
  10. In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
    Authors: Morecroft Et al.
    Int J Neuropsychopharmacol 2010;85:593
  11. Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses.
    Authors: Watakabe Et al.
    Br J Pharmacol 2009;19:1915
  12. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
    Authors: González-Maeso Et al.
    Mol Ther 2007;53:439
  13. 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor.
    Authors: Morecroft Et al.
    Obesity (Silver Spring) 1999;128:730
Expand to show all 13 Citations

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