Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate
Biological ActivityKetanserin tartrate is a selective 5-HT2A serotonin receptor antagonist; can also be used to discriminate between 5-HT1D and 5-HT1B receptor subtypes.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Receptor binding profile of R41 468, a novel antagonist at 5-HT2 receptors.
Leyson et al.
Life Sci., 1981;28:1015
Differences in the effects of ketanserin and GR 127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein.
Razzaque et al.
Vascular effects of ketanserin (R41 468), a novel antagonist of 5-HT2 serotonergic receptors.
Van Nueten et al.
Ketanserin and ritanserin discriminate between recombinant human 5-HT1Dα and 5-HT1Dβ receptor subtypes.
Zgombick et al.
Citations for Ketanserin tartrate
The citations listed below are publications that use Tocris products. Selected citations for Ketanserin tartrate include:
22 Citations: Showing 1 - 10
Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.
Authors: Nguyen Et al.
Korean J Physiol Pharmacol 2019;23:271
Maternal Regulation of Pups' Cortical Activity: Role of Serotonergic Signaling.
Authors: Courtiol Et al.
Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
Authors: Medrihan Et al.
Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors.
Authors: Jiang Et al.
Br J Pharmacol 2015;89:342
Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens.
Authors: Kasper Et al.
Behavioral and neurochemical changes in mesostriatal DArgic regions of the rat after chronic administration of the cannabinoid receptor agonist WIN55,212-2.
Authors: Fanarioti Et al.
A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases.
Authors: Kuo Et al.
Int J Biol Sci 2014;10:64
Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival.
Authors: Saxena Et al.
Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass.
Authors: Ratner Et al.
Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension.
Authors: Morecroft Et al.
Cereb Cortex 2012;20:1516
Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production.
Authors: Wood Et al.
J Neurosci 2011;31:13808
Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster.
Authors: Johnson Et al.
Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation.
Authors: Kleinbongard Et al.
Circ Res 2011;108:344
In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
Authors: Morecroft Et al.
Int J Neuropsychopharmacol 2010;85:593
Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.
Authors: Huang Et al.
Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses.
Authors: Watakabe Et al.
Br J Pharmacol 2009;19:1915
Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat.
Br J Pharmacol 2008;155:343
Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
Authors: González-Maeso Et al.
Mol Ther 2007;53:439
Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
Authors: Hampson Et al.
Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous.
Authors: Marinelli Et al.
J Neurophysiol 2004;92:3532
5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor.
Authors: Morecroft Et al.
Obesity (Silver Spring) 1999;128:730
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