Chemical Name: 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
Biological Activity5-Azacytidine is a DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
5-aza-Cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms.
Schneider-Stock et al.
Dissecting direct reprogramming through integrative genomic analysis.
Mikkelsen et al.
5-Azacytidine induces cardiac differentiation of human umbilical cord-derived mesenchymal stem cells by activating extracellular regulated kinase.
Qian et al.
Stem Cells Dev., 2012;21:67
Citations for 5-Azacytidine
The citations listed below are publications that use Tocris products. Selected citations for 5-Azacytidine include:
5 Citations: Showing 1 - 5
TET1 regulates fibroblast growth factor 8 transcription in Gn releasing hormone neurons.
Authors: Linscott and Chung
PLoS One 2019;14:e0220530
PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells
Authors: Chandrakanthan Et al.
Proc Natl Acad Sci U S A 2016;113:E2306
5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.
Authors: Bhuvanagiri Et al.
EMBO Mol Med 2014;6:1593
Progenitor cells identified by PDGFR-α expression in the developing and diseased human heart.
Authors: Chong Et al.
Cell Res 2013;22:1932
Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma.
Authors: Perera Et al.
PLoS One 2009;4:e4488
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