Chemical Name: 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
Biological ActivityDNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
5-aza-Cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms.
Schneider-Stock et al.
Dissecting direct reprogramming through integrative genomic analysis.
Mikkelsen et al.
5-Azacytidine induces cardiac differentiation of human umbilical cord-derived mesenchymal stem cells by activating extracellular regulated kinase.
Qian et al.
Stem Cells Dev., 2012;21:67
Citations for 5-Azacytidine
The citations listed below are publications that use Tocris products. Selected citations for 5-Azacytidine include:
4 Citations: Showing 1 - 4
PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells
Authors: Chandrakanthan Et al.
Proc Natl Acad Sci U S A 2016;113:E2306
5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.
Authors: Bhuvanagiri Et al.
EMBO Mol Med 2014;6:1593
Progenitor cells identified by PDGFR-α expression in the developing and diseased human heart.
Authors: Chong Et al.
Cell Res 2013;22:1932
Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma.
Authors: Perera Et al.
PLoS One 2009;4:e4488
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