DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
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All Tocris products are intended for laboratory research use only.
5-aza-Cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms.
Schneider-Stock et al.
Dissecting direct reprogramming through integrative genomic analysis.
Mikkelsen et al.
5-Azacytidine induces cardiac differentiation of human umbilical cord-derived mesenchymal stem cells by activating extracellular regulated kinase.
Qian et al.
Stem Cells Dev., 2012;21:67
The citations listed below are publications that use Tocris products. Selected citations for 5-Azacytidine include:
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