5-Azacytidine

  ( 4 citations )    
Product Datasheet
Catalog Number:3842
Chemical Name:4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
Product Details
Citations (4)
Reviews
Biological Activity
DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
Technical Data
  • M.Wt:
    244.2
  • Formula:
    C8H12N4O5
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    320-67-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for 5-Azacytidine include:

4 Citations: Showing 1 - 4
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  1. PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells
    Authors: Chandrakanthan Et al.
    Proc Natl Acad Sci U S A  2016;113:E2306
  2. 5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.
    Authors: Bhuvanagiri Et al.
    EMBO Mol Med  2014;6:1593
  3. Progenitor cells identified by PDGFR-α expression in the developing and diseased human heart.
    Authors: Chong Et al.
    Cell Res  2013;22:1932
  4. Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma.
    Authors: Perera Et al.
    PLoS One  2009;4:e4488

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