Catalog Number: 0458
Alternate Names: AH-21467, 5-CT
Biological Activity
5-HT1 agonist with high affinity at 5-HT1A, 5-HT1B, 5-HT1D, 5-ht5 and 5-HT7 receptors.
Technical Data
  • M.Wt:
    319.32
  • Formula:
    C11H13N3O.C4H4O4
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    74885-72-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. An investigation of the 5-HT1D receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatriptan in the central nervous system of seven species.
    Beer et al.
    Eur.J.Pharmacol., 1992;213:193
  2. [3H]-5-carboxamidotryptamine labels 5HT1D binding sites in bovine substantia nigra.
    Nowak et al.
    Br.J.Pharmacol., 1993;109:1206
  3. 5-Hydroxytryptamine receptors.
    Zifa and Fillion
    Pharmacol.Rev., 1992;44:401
  4. Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor.
    Wood et al.
    Eur.J.Pharmacol., 2000;396:1
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 5-Carboxamidotryptamine maleate include:

9 Citations: Showing 1 - 9
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  1. Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix
    Authors: Bijata Et al.
    Cell Rep 2017;19:1767
  2. Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels
    Authors: Sargin Et al.
    Elife 2016;5:e21416
  3. 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts.
    Authors: Chien and Su
    PLoS One 2015;22:42
  4. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
    Authors: Montalbano Et al.
    Br J Pharmacol 2015;10:e0140369
  5. Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor.
    Authors: Gantz Et al.
    Am J Physiol Renal Physiol 2013;78:807
  6. Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation.
    Authors: Kim Et al.
    Neuron 2013;190:4795
  7. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: Müller Et al.
    PLoS One 2009;4:e6453
  8. Serotonin targets inhibitory synapses to induce modulation of network functions.
    Authors: Manzke Et al.
    Philos Trans R Soc Lond B Biol Sci 2009;364:2589
  9. 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor.
    Authors: Morecroft Et al.
    J Immunol 1999;128:730

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