5'-Fluoroindirubinoxime

Key Product Details

Product Description

5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC₅₀ = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).

Licensing Information

Sold under licence from Anygen Co. Ltd.

Product Specifications for 5'-Fluoroindirubinoxime

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 5'-Fluoroindirubinoxime

The following data is based on the product molecular weight 295.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.39 mL	16.93 mL	33.87 mL
5 mM	0.68 mL	3.39 mL	6.77 mL
10 mM	0.34 mL	1.69 mL	3.39 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Krivogorsky Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. Antimicrob.Agents Chemother. 2008 PMID: 18824607
• Choi Indiribuin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg.Med.Chem.Lett. 2010 PMID: 20153646
• Kim Antitumor activity of novel indirubin derivatives in rat tumor model. Clin.Cancer Res. 2007 PMID: 17200363

Product Documents for 5'-Fluoroindirubinoxime