5'-Fluoroindirubinoxime

Catalog # Availability Size / Price Qty
4033/10
4033/50
5'-Fluoroindirubinoxime | CAS No. 861214-33-7 | Flt-3 Inhibitors
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Description: FLT3 inhibitor; displays antiproliferative activity

Chemical Name: 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione 3-oxime

Purity: ≥99%

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Biological Activity

Inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC50 = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).

Technical Data

M.Wt:
295.27
Formula:
C16H10FN3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
861214-33-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under licence from Anygen Co. Ltd.

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