Chemical Name: 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione 3-oxime
Biological Activity5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC50 = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Antitumor activity of novel indirubin derivatives in rat tumor model.
Kim et al.
Clin.Cancer Res., 2007;13:253
Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.
Krivogorsky et al.
Antimicrob.Agents Chemother., 2008;52:4466
Indiribuin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells.
Choi et al.
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