Catalog Number: 4033
Chemical Name: 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione 3-oxime
Biological Activity
Inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC50 = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).
Technical Data
  • M.Wt:
    295.27
  • Formula:
    C16H10FN3O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    861214-33-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under licence from Anygen Co. Ltd.
Background References
  1. Antitumor activity of novel indirubin derivatives in rat tumor model.
    Kim et al.
    Clin.Cancer Res., 2007;13:253
  2. Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.
    Krivogorsky et al.
    Antimicrob.Agents Chemother., 2008;52:4466
  3. Indiribuin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells.
    Choi et al.
    Bioorg.Med.Chem.Lett., 2010;20:2033

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