Chemical Name: N-[[(6-Hydroxy-1-naphthalenyl)amino]thioxomethyl]-2-furancarboxamide
Biological ActivityCalcium release-activated calcium (CRAC) channel blocker. Blocks store-operated calcium entry (SOCE) in HeLa-O+S cells and Th17 cells in vitro. Ameliorates symptoms and reduces CNS infiltration by mononuclear cells in a mouse model of experimental autoimmune encephalomyelitis (EAE) in vivo.
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Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.
Kim et al.
Citation for 5J 4
The citations listed below are publications that use Tocris products. Selected citations for 5J 4 include:
1 Citation: Showing 1 - 1
Homer1a attenuates glutamate-induced oxidative injury in HT-22 cells through regulation of store-operated calcium entry.
Authors: Rao Et al.
Sci Rep 2016;6:33975
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