6-Chloromelatonin (CAS 63762-74-3): R&D Systems
Catalog Number: 0443
Chemical Name: N-[2-(6-Chloro-5-methoxyindol-3-yl)ethyl]acetamide
Biological Activity
Potent melatonin agonist (pKi values are 9.10 and 9.77 for human recombinant MT1 and MT2 receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.
Technical Data
  • M.Wt:
    266.73
  • Formula:
    C13H15ClN2O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    63762-74-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Luzindole (NO 774): a novel melatonin receptor antagonist.
    Dubocovich
    J.Pharmacol.Exp.Ther., 1988;246:902
  2. Melatonin receptors: are there multiple subtypes?
    Dubocovich
    TiPS, 1995;16:50
  3. Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors.
    Browning et al.
    Br.J.Pharmacol., 2000;129:877
  4. 2-[125I]Iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution.
    Duncan et al.
    Endocrinology, 1988;122:1825

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