Chemical Name: 2,5-Dihydroxy-DL-tyrosine
Biological Activity6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC50 = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule inhibitors of DNA repair nuclease activities of APE1.
Wilson DM 3rd et al.
Cell Mol.Life Sci., 2010;67:3621
Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.
Simeonov et al.
PLoS One, 2009;4:e5740
Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.
Chandramouly et al.
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