6-Hydroxy-DL-DOPA

Key Product Details

Product Description

6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC₅₀ = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1.

Product Specifications for 6-Hydroxy-DL-DOPA

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 6-Hydroxy-DL-DOPA

The following data is based on the product molecular weight 213.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.69 mL	23.45 mL	46.91 mL
5 mM	0.94 mL	4.69 mL	9.38 mL
10 mM	0.47 mL	2.35 mL	4.69 mL
50 mM	0.09 mL	0.47 mL	0.94 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Simeonov Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 2009 PMID: 19484131
• Chandramouly Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem.Biol. 2015 PMID: 26548611
• Wilson DM 3rd Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol.Life Sci. 2010 PMID: 20809131

Product Documents for 6-Hydroxy-DL-DOPA