666-15
Chemical Name: 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride
Purity: ≥98%
Biological Activity
Potent and selective CREB inhibitor (IC50 = 81 nM). Inhibits cancer cell growth, without harming normal cells (up to 1 μM). Completely suppresses tumor growth in a breast cancer xenograft model.Technical Data
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
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Identification of a potent inhibitor of CREB-mediated gene transcription with efficacious in vivo anticancer activity
Xie et al.
J.Med.Chem., 2015;58:5075 -
Systemic inhibition of CREB is well-tolerated in vivo.
Li et al.
Sci.Rep., 2016;6:34513
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Citation for 666-15
The citations listed below are publications that use Tocris products. Selected citations for 666-15 include:
1 Citation: Showing 1 - 1
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Angiopoietin-like 4 mediates colonic inflammation by regulating chemokine transcript stability via tristetraprolin.
Authors: Phua
Sci Rep 2017;7:44351
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