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666-15 | CAS No. 1433286-70-4 | Additional Transcription Factor Compounds
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Description: Potent and selective CREB inhibitor

Chemical Name: 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (21)
Reviews (1)

Biological Activity

666-15 is a potent and selective CREB inhibitor (IC50 = 81 nM). Inhibits cancer cell growth, without harming normal cells (up to 1 μM). Completely suppresses tumor growth in a breast cancer xenograft model.

Technical Data

Soluble to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for 666-15

The citations listed below are publications that use Tocris products. Selected citations for 666-15 include:

21 Citations: Showing 1 - 10

  1. Adenosine receptors differentially mediate enteric glial cell death induced by Clostridioides difficile Toxins A and B.
    Authors: Cirle A Et al.
    Front Immunol  2023;13:956326
  2. SS18-SSX drives CREB activation in synovial sarcoma.
    Authors: Konrad Et al.
    Cell Oncol (Dordr)  2022;45:399-413
  3. Molecular and cellular mechanisms for differential effects of chronic social isolation stress in males and females.
    Authors: Ping Et al.
    Mol Psychiatry  2022;27:3056-3068
  4. G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis.
    Authors: Jiehan Et al.
    Nat Commun  2022;13:7408
  5. MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization.
    Authors: Qing Et al.
    Sci Rep  2022;12:4183
  6. Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signalling.
    Authors: Qinkun Et al.
    Cardiovasc Res  2022;118:2124-2138
  7. Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival.
    Authors: Israel Et al.
    JCI Insight  2021;6
  8. Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation.
    Authors: Asya Et al.
    Immunity  2021;54:1022-1036.e8
  9. Mycobacterium avium subsp. paratuberculosis MAP1889c Protein Induces Maturation of Dendritic Cells and Drives Th2-biased Immune Responses.
    Authors: Hwa-Jung Et al.
    Cells  2020;9
  10. Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1.
    Authors: Chris Et al.
    Elife  2020;9
  11. A dopamine-induced gene expression signature regulates neuronal function and cocaine response.
    Authors: Lara Et al.
    Sci Adv  2020;6:eaba4221
  12. Osmotic and hypoxic induction of osteopontin in retinal pigment epithelial cells: Involvement of purinergic receptor signaling.
    Authors: Andreas Et al.
    Mol Vis  2020;26:188-203
  13. A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling.
    Authors: Martin Et al.
    PLoS Genet  2020;16:e1009103
  14. Resolvin E1 is a pro-repair molecule that promotes intestinal epithelial wound healing.
    Authors: Asma Et al.
    Proc Natl Acad Sci U S A  2020;117:9477-9482
  15. Nutritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages.
    Authors: O'Reilly Et al.
    Mol Nutr Food Res  2019;63:e1800713
  16. PML hyposumoylation is responsible for the resistance of pancreatic cancer.
    Authors: Juan L Et al.
    FASEB J  2019;33:12447-12463
  17. Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain.
    Authors: Zhou Et al.
    Cell Rep  2019;27:3844
  18. Signal Transduction of Improving Effects of Ibudilast on Methamphetamine Induced Cell Death.
    Authors: Reza Et al.
    Asian Pac J Cancer Prev  2019;20:2763-2774
  19. Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.
    Authors: Hamnett Et al.
    Nat Commun  2019;10:542
  20. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
    Authors: Kleiner Et al.
    Mol Vis  2018;24:647
  21. Angiopoietin-like 4 mediates colonic inflammation by regulating chemokine transcript stability via tristetraprolin.
    Authors: Phua
    Sci Rep  2017;7:44351


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creb inhibitor
By Anonymous on 05/02/2018

drug treatment with different conc from 1nm-5um

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