Chemical Name: 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride
Biological Activity666-15 is a potent and selective CREB inhibitor (IC50 = 81 nM). Inhibits cancer cell growth, without harming normal cells (up to 1 μM). Completely suppresses tumor growth in a breast cancer xenograft model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a potent inhibitor of CREB-mediated gene transcription with efficacious in vivo anticancer activity
Xie et al.
Systemic inhibition of CREB is well-tolerated in vivo.
Li et al.
Citations for 666-15
The citations listed below are publications that use Tocris products. Selected citations for 666-15 include:
5 Citations: Showing 1 - 5
Nutritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages.
Authors: O'Reilly Et al.
Mol Nutr Food Res 2019;63:e1800713
Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain.
Authors: Zhou Et al.
Cell Rep 2019;27:3844
Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.
Authors: Hamnett Et al.
Nat Commun 2019;10:542
Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
Authors: Kleiner Et al.
Mol Vis 2018;24:647
Angiopoietin-like 4 mediates colonic inflammation by regulating chemokine transcript stability via tristetraprolin.
Sci Rep 2017;7:44351
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drug treatment with different conc from 1nm-5um