666-15
Chemical Name: 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride
Purity: ≥98%
Biological Activity
666-15 is a potent and selective CREB inhibitor (IC50 = 81 nM). Inhibits cancer cell growth, without harming normal cells (up to 1 μM). Completely suppresses tumor growth in a breast cancer xenograft model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of a potent inhibitor of CREB-mediated gene transcription with efficacious in vivo anticancer activity
Xie et al.
J.Med.Chem., 2015;58:5075 -
Systemic inhibition of CREB is well-tolerated in vivo.
Li et al.
Sci.Rep., 2016;6:34513
Product Datasheets
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Citations for 666-15
The citations listed below are publications that use Tocris products. Selected citations for 666-15 include:
5 Citations: Showing 1 - 5
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Nutritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages.
Authors: O'Reilly Et al.
Mol Nutr Food Res 2019;63:e1800713
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Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain.
Authors: Zhou Et al.
Cell Rep 2019;27:3844
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Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.
Authors: Hamnett Et al.
Nat Commun 2019;10:542
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Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
Authors: Kleiner Et al.
Mol Vis 2018;24:647
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Angiopoietin-like 4 mediates colonic inflammation by regulating chemokine transcript stability via tristetraprolin.
Authors: Phua
Sci Rep 2017;7:44351
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