666-15

Tocris Bioscience | Catalog # 5661

Potent and selective CREB inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective CREB inhibitor
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Product Description

666-15 is a potent and selective CREB inhibitor (IC50 = 81 nM). Inhibits cancer cell growth, without harming normal cells (up to 1 μM). Completely suppresses tumor growth in a breast cancer xenograft model.

Product Specifications for 666-15

Molecular Weight

620.52

Formula

C33H30ClN3O5.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride

CAS Number

1433286-70-4

PubChem ID

71566396

InChI Key

LELLCPHHYHLWBH-UHFFFAOYSA-N

SMILES

NCCCOC1=CC2=CC=CC=C2C=C1C(NCCOC3=C(C(NC4=CC=C(Cl)C=C4O)=O)C=C(C=CC=C5)C5=C3)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 62.05 100

Preparing Stock Solutions for 666-15

The following data is based on the product molecular weight 620.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.61 mL 8.06 mL 16.12 mL
5 mM 0.32 mL 1.61 mL 3.22 mL
10 mM 0.16 mL 0.81 mL 1.61 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 40 publications citing the usage of this product.

Product Documents for 666-15

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 666-15

For research use only

Customer Reviews for 666-15 (1)

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  • creb inhibitor
    Name: Anonymous
    Cell Line/Tissue: pancreatic cancer cell
    Verified Customer | Posted 05/02/2018
    drug treatment with different conc from 1nm-5um

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