673 A

Key Product Details

Product Description

673 A is an aldehyde dehydrogenase (ALDH1A) inhibitor (IC₅₀ values are 230, 246 and 348 nM for ALDH1A2, ALDH1A1 and ALDH1A3, respectively). Exhibits >40-fold selectivity for ALD1A over ALDH2. Depletes CD133⁺ cancer stem cells (CSC) in ovarian cancer cell lines. Triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). Overcomes chemotherapy resistance in vivo.

Product Specifications for 673 A

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 673 A

The following data is based on the product molecular weight 223.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.96 mL	44.79 mL	89.57 mL
2.5 mM	1.79 mL	8.96 mL	17.91 mL
5 mM	0.90 mL	4.48 mL	8.96 mL
25 mM	0.18 mL	0.90 mL	1.79 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Raghavan Personalized medicine-based approach to model patterns of chemoresistance and tumor recurrence using ovarian cancer stem cell spheroids. Clin.Cancer Res. 2017 PMID: 28814433
• Chefetz A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells. Cell Rep. 2019 PMID: 30865894

Product Documents for 673 A