673 A New
Chemical Name: 4-(1,3-Dihydro-2H-isoindol-2-yl)benzaldehyde
Biological ActivityAldehyde dehydrogenase (ALDH1A) inhibitor (IC50 values are 230, 246 and 348 nM for ALDH1A2, ALDH1A1 and ALDH1A3, respectively). Exhibits >40-fold selectivity for ALD1A over ALDH2. Depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. Triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). Overcomes chemotherapy resistance in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells.
Chefetz et al.
Cell Rep., 2019;26:3061
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