673 A

Catalog # Availability Size / Price Qty
6934/10
6934/50
Aldehyde Dehydrogenase Inhibitors Small Molecule
1 Image
Description: ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)

Chemical Name: 4-(1,3-Dihydro-2H-isoindol-2-yl)benzaldehyde

Purity: ≥98%

Product Details
Reviews

Biological Activity

Aldehyde dehydrogenase (ALDH1A) inhibitor (IC50 values are 230, 246 and 348 nM for ALDH1A2, ALDH1A1 and ALDH1A3, respectively). Exhibits >40-fold selectivity for ALD1A over ALDH2. Depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. Triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). Overcomes chemotherapy resistance in vivo.

Technical Data

M.Wt:
223.28
Formula:
C15H13NO
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
109437-62-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells.
    Chefetz et al.
    Cell Rep., 2019;26:3061

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for 673 A

There are currently no reviews for this product. Be the first to review 673 A and earn rewards!

Have you used 673 A?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.