673 A
1 Image
Description: ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)
Chemical Name: 4-(1,3-Dihydro-2H-isoindol-2-yl)benzaldehyde
Purity: ≥98%
Biological Activity
673 A is an aldehyde dehydrogenase (ALDH1A) inhibitor (IC50 values are 230, 246 and 348 nM for ALDH1A2, ALDH1A1 and ALDH1A3, respectively). Exhibits >40-fold selectivity for ALD1A over ALDH2. Depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. Triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). Overcomes chemotherapy resistance in vivo.Technical Data
M.Wt:
223.28
Formula:
C15H13NO
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
109437-62-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells.
Chefetz et al.
Cell Rep., 2019;26:3061 -
Personalized medicine-based approach to model patterns of chemoresistance and tumor recurrence using ovarian cancer stem cell spheroids.
Raghavan et al.
Clin.Cancer Res., 2017;23:6934
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for 673 A
There are currently no reviews for this product. Be the first to review 673 A and earn rewards!
Have you used 673 A?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris Bioscience is the leading supplier of novel and exclusive
tools for
life science research with over 30 years' experience in the
industry.
Tocris is a Bio-Techne brand.
