Catalog Number: 5602
Chemical Name: 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
Biological Activity
CD40-TRAF6 interaction inhibitor. Suppresses CD40-induced IL-1β and IL-6 expression in macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in diet-induced obese mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.
    Chatzigeorgiou et al.
    Proc.Natl.Acad.Sci.U.S.A., 2014;111:2686
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