6877002

Catalog # Availability Size / Price Qty
5602/10
5602/50
Cat.No. 5602 - 6877002 | C17H17NO | CAS No. 433249-94-6
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Description: CD40-TRAF6 interaction inhibitor

Chemical Name: 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one

Purity: ≥99%

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Biological Activity

CD40-TRAF6 interaction inhibitor. Suppresses CD40-induced IL-1β and IL-6 expression in macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in diet-induced obese mice.

Technical Data

M.Wt:
251.32
Formula:
C17H17NO
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
433249-94-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.
    Chatzigeorgiou et al.
    Proc.Natl.Acad.Sci.U.S.A., 2014;111:2686

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