Chemical Name: 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
Biological ActivityCD40-TRAF6 interaction inhibitor. Suppresses CD40-induced IL-1β and IL-6 expression in macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in diet-induced obese mice.
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Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated Ins resistance.
Chatzigeorgiou et al.
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