CD40-TRAF6 interaction inhibitor. Suppresses CD40-induced IL-1β
and IL-6 expression in macrophages in vitro
. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in diet-induced obese mice.
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Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.
Chatzigeorgiou et al.