Catalog Number: 5402
Chemical Name: (3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide
Biological Activity
Insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 1 mg/ml in water
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purpose under license from Harvard University
Other Product-Specific Information:
  • This compound is supplied in net weight as the TFA salt.
Background References
  1. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.
    Maianti et al.
    Nature, 2014;511:94
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