6bK

Tocris Bioscience | Catalog # 5402

Insulin degrading enzyme (IDE) inhibitor
Tocris Bioscience

Key Product Details

Description

Insulin degrading enzyme (IDE) inhibitor
View all Other Insulin and Insulin-like Receptor Products »

Product Description

6bK is an insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.

This compound is supplied in net weight as the TFA salt.

Licensing Information

Sold for research purpose under license from Harvard University

Product Specifications for 6bK

Molecular Weight

757.92

Formula

C41H55N7O7

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide

CAS Number

1417537-93-9

PubChem ID

91758793

InChI Key

BHZABWWULWHRIY-JAXGQCOVSA-N

SMILES

NC([C@@H](NC(/C=C/C(N[C@@H](CCCCN)C(N[C@H](C(N3)=O)CC2CCCCC2)=O)=O)=O)CCCCNC([C@H]3CC1=CC=C(C(C4=CC=CC=C4)=O)C=C1)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1 2

Preparing Stock Solutions for 6bK

The following data is based on the product molecular weight 757.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.02 mM 65.97 mL 329.85 mL 659.70 mL
0.1 mM 13.19 mL 65.97 mL 131.94 mL
0.2 mM 6.60 mL 32.99 mL 65.97 mL
1 mM 1.32 mL 6.60 mL 13.19 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Product Documents for 6bK

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 6bK

For research use only

Customer Reviews for 6bK

There are currently no reviews for this product. Be the first to review 6bK and earn rewards!

Have you used 6bK?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card