Catalog Number: 1983
Alternate Names: PDGFR740Y-P
Biological Activity
Cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Tyr-21 = pTyr)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway.
    Williams and Doherty
    Mol.Cell.Neurosci., 1999;13:272
  2. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide.
    Derossi et al.
    Biochem.Biophys.Res.Comm., 1998;251:148

The citations listed below are publications that use Tocris products. Selected citations for 740 Y-P include:

6 Citations: Showing 1 - 6
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  1. Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway.
    Authors: Sun Et al.
    J Assist Reprod Genet 2015;83:86
  2. New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators.
    Authors: Sun Et al.
    Cell Cycle 2015;14:721
  3. Attempted application of bioengineered/biosynthetic supporting matrices with phosphatidylinositol-trisphosphate-enhancing substances to organ culture of human primordial follicles.
    Authors: Lerer-Serfaty Et al.
    Proc Natl Acad Sci U S A 2013;30:1279
  4. Age-dependent regulation of synaptic connections by dopamine D2 receptors.
    Authors: Jia Et al.
    Nat Neurosci 2013;16:1627
  5. The expression and relaxant effect of bitter taste receptors in human bronchi.
    Authors: Grassin-Delyle Et al.
    Respir Res 2013;14:134
  6. Activation of dormant ovarian follicles to generate mature eggs.
    Authors: Li Et al.
    Nat Commun 2010;107:10280

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