Catalog Number: 1983
Alternate Names: PDGFR740Y-P
Biological Activity
Cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Tyr-21 = pTyr)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway.
    Williams and Doherty
    Mol.Cell.Neurosci., 1999;13:272
  2. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide.
    Derossi et al.
    Biochem.Biophys.Res.Comm., 1998;251:148
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