740 Y-P

Catalog # Availability Size / Price Qty
1983/1
Cat.No. 1983 - 740 Y-P | Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-pTyr-Met-Asp-Met-Ser | CAS No. 1236188-16-1
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Description: Cell-permeable PI 3-kinase activator
Alternative Names: PDGFR740Y-P
Product Details
Citations (8)
Reviews (1)

Biological Activity

Cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.

Technical Data

M.Wt:
3270.72
Formula:
C141H222N43O39PS3
Sequence:
RQIKIWFQNRRMKWKKSDGGYMDMS

(Modifications: Tyr-21 = pTyr)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
1236188-16-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway.
    Williams and Doherty
    Mol.Cell.Neurosci., 1999;13:272
  2. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide.
    Derossi et al.
    Biochem.Biophys.Res.Comm., 1998;251:148

Product Datasheets

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Citations for 740 Y-P

The citations listed below are publications that use Tocris products. Selected citations for 740 Y-P include:

8 Citations: Showing 1 - 8

FAQs

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in vitro PI3K activation
By Anonymous on 07/12/2018
Species: Human

Added in culture medium to promote PI3K pathway


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