Biological Activity740 Y-P is a cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.
(Modifications: Tyr-21 = pTyr)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway.
Williams and Doherty
Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide.
Derossi et al.
Citations for 740 Y-P
The citations listed below are publications that use Tocris products. Selected citations for 740 Y-P include:
10 Citations: Showing 1 - 10
In vitro Activation Prior to Transplantation of Human Ovarian Tissue: Is It Truly Effective?
Authors: Dolmans Et al.
Front Endocrinol (Lausanne) 2019;10:520
Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells.
Authors: Drelich Et al.
Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway.
Authors: Sun Et al.
J Assist Reprod Genet 2015;83:86
Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization.
Authors: Lomakin Et al.
Nat Cell Biol 2015;17:1435
New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators.
Authors: Sun Et al.
Cell Cycle 2015;14:721
Attempted application of bioengineered/biosynthetic supporting matrices with phosphatidylinositol-trisphosphate-enhancing substances to organ culture of human primordial follicles.
Authors: Lerer-Serfaty Et al.
Proc Natl Acad Sci U S A 2013;30:1279
Age-dependent regulation of synaptic connections by DA D2 receptors.
Authors: Jia Et al.
Nat Neurosci 2013;16:1627
The expression and relaxant effect of bitter taste receptors in human bronchi.
Authors: Grassin-Delyle Et al.
Respir Res 2013;14:134
Apoptosis resistance and PKC signaling: distinguishing features of high and low metastatic cells.
Authors: Hong Et al.
Activation of dormant ovarian follicles to generate mature eggs.
Authors: Li Et al.
Nat Commun 2010;107:10280
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