740 Y-P

Catalog # Availability Size / Price Qty
1983/1
740 Y-P
1 Image
Description: Cell-permeable PI 3-kinase activator
Alternative Names: PDGFR740Y-P
Product Details
Citations (10)
Reviews (1)

Biological Activity

Cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.

Technical Data

M.Wt:
3270.72
Formula:
C141H222N43O39PS3
Sequence:
RQIKIWFQNRRMKWKKSDGGYMDMS

(Modifications: Tyr-21 = pTyr)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
1236188-16-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway.
    Williams and Doherty
    Mol.Cell.Neurosci., 1999;13:272
  2. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide.
    Derossi et al.
    Biochem.Biophys.Res.Comm., 1998;251:148

Product Datasheets

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Citations for 740 Y-P

The citations listed below are publications that use Tocris products. Selected citations for 740 Y-P include:

10 Citations: Showing 1 - 10

  1. In vitro Activation Prior to Transplantation of Human Ovarian Tissue: Is It Truly Effective?
    Authors: Dolmans Et al.
    Front Endocrinol (Lausanne)  2019;10:520
  2. Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells.
    Authors: Drelich Et al.
    Viruses  2018;10
  3. Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway.
    Authors: Sun Et al.
    J Assist Reprod Genet  2015;83:86
  4. Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization.
    Authors: Lomakin Et al.
    Nat Cell Biol  2015;17:1435
  5. New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators.
    Authors: Sun Et al.
    Cell Cycle  2015;14:721
  6. Attempted application of bioengineered/biosynthetic supporting matrices with phosphatidylinositol-trisphosphate-enhancing substances to organ culture of human primordial follicles.
    Authors: Lerer-Serfaty Et al.
    Proc Natl Acad Sci U S A  2013;30:1279
  7. Age-dependent regulation of synaptic connections by DA D2 receptors.
    Authors: Jia Et al.
    Nat Neurosci  2013;16:1627
  8. The expression and relaxant effect of bitter taste receptors in human bronchi.
    Authors: Grassin-Delyle Et al.
    Respir Res  2013;14:134
  9. Apoptosis resistance and PKC signaling: distinguishing features of high and low metastatic cells.
    Authors: Hong Et al.
    Neoplasia  2012;14:249
  10. Activation of dormant ovarian follicles to generate mature eggs.
    Authors: Li Et al.
    Nat Commun  2010;107:10280

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in vitro PI3K activation
By Anonymous on 07/12/2018
Application: Species: Human

Added in culture medium to promote PI3K pathway


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