740 Y-P

Tocris Bioscience | Catalog # 1983

Cell-permeable PI 3-kinase activator
Tocris Bioscience

Key Product Details

Description

Cell-permeable PI 3-kinase activator

Alternative Names

PDGFR740Y-P
View all PI 3-Kinase Activators »

Product Description

740 Y-P is a cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.

Product Specifications for 740 Y-P

Molecular Weight

3270.72

Formula

C141H222N43O39PS3

Storage

Store at -20°C

Purity

≥85% (HPLC)

CAS Number

1236188-16-1

PubChem ID

90488730

InChI Key

XCGMILZGRGEWHL-QYGSNONCSA-N

SMILES

[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(OP(O)(O)=O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 68 publications citing the usage of this product.

Product Documents for 740 Y-P

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 740 Y-P

For research use only

Customer Reviews for 740 Y-P (1)

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  • in vitro PI3K activation
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: MCF10A
    Verified Customer | Posted 07/12/2018
    Not sure if it is working or not Wish larger amounts with discount were available
    Added in culture medium to promote PI3K pathway

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