8-Aminoadenine
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Description: Adenine receptor agonist
Chemical Name: 9H-Purine-6,8-diamine
Purity: ≥98%
Biological Activity
8-Aminoadenine is an adenine receptor agonist (Ki = 0.0341 μM in HEK293 cells expressing an adenine binding site). Displays 190-fold increased potency at the human binding site over the rat adenine receptor (rAde1R) (Ki = 6.51 μM).Technical Data
M.Wt:
150.14
Formula:
C5H6N6
Solubility:
Soluble to 100 mM in 2eq.HCl and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
28128-33-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family.
Borrmann et al.
J.Med.Chem., 2009;52:5974 -
Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.
Bender et al.
Proc.Natl.Acad.Sci., 2002;99:8573
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