Chemical Name: 3-β-D-Ribofuranosyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine
Biological Activity8-Azaadenosine is an ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. Reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
ADAR1 activation drives leukemia stem cell self-renewal by impairing let-7 biogenesis.
Zipeto et al.
Cell Stem Cell, 2016;19:177
ADARs edit microRNAs to promote leukemic stem cell activity.
Zhang and Slack et al.
Cell Stem Cell, 2016;19:141
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