8-Azaadenosine

Key Product Details

Product Description

8-Azaadenosine is an ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. Reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.

Product Specifications for 8-Azaadenosine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 8-Azaadenosine

The following data is based on the product molecular weight 268.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.73 mL	18.64 mL	37.28 mL
5 mM	0.75 mL	3.73 mL	7.46 mL
10 mM	0.37 mL	1.86 mL	3.73 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Zhang and Slack ADARs edit microRNAs to promote leukemic stem cell activity. Cell Stem Cell 2016 PMID: 27494666
• Zipeto ADAR1 activation drives leukemia stem cell self-renewal by impairing let-7 biogenesis. Cell Stem Cell 2016 PMID: 27292188

Product Documents for 8-Azaadenosine